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| 激素联合丙种球蛋白治疗多发性硬化的临床研究 | |
| 引用本文： | 孟庆萍,王嘉俊,冯娟,焦彦岭,潘月. 激素联合丙种球蛋白治疗多发性硬化的临床研究[J]. 实用药物与临床, 2011, 14(3): 200-202 |
| 作者姓名： | 孟庆萍 王嘉俊 冯娟 焦彦岭 潘月 |
| 作者单位： | 1. 中国医科大学附属盛京医院神经内科,沈阳,110004 2. 中国医科大学,沈阳,110001 3. 锦州市中心医院,锦州,121000 4. 沈阳维康医院,沈阳,110021 |
| 基金项目： | 辽宁省科学技术计划项目 |
| 摘 要： | 目的探讨激素联合丙种球蛋白治疗多发性硬化(MS)的疗效。方法随机将41例多发性硬化患者分为激素联合丙球治疗组(20例,联合组)和单纯应用激素治疗组(对照组,21例)。两组均用激素治疗,联合组另给丙种球蛋白0.4 g/kg,每日1次静脉注射,连续治疗5 d。所有患者在治疗前和开始治疗后的3周,均检测临床及免疫学指标。结果联合组治疗后,EDSS评分与治疗前比较,差异有统计学意义(P<0.01)。联合组治疗后与同组治疗前、对照组治疗后比较,IFN-γ的水平差异具有统计学意义(P<0.05),联合组治疗后与同组治疗前、对照组治疗后比较,IL-6的水平差异具有统计学意义(P<0.05);而治疗后联合组IL-10的水平明显高于对照组(P<0.05)。结论激素联合丙种球蛋白治疗多发性硬化,可通过非特异性的免疫调节机制调节机体的免疫功能,对多发性硬化的异常免疫应答起调节作用,可有效改善患者症状。 |
| 关 键 词： | 多发性硬化 激素 丙种球蛋白 |
Effect of immunoglobulin with hormone treatment for multiple sclerosis |
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| MENG Qing-ping,WANG Jia-jun,FENG Juan,JIAO Yan-ling,PAN Yue. Effect of immunoglobulin with hormone treatment for multiple sclerosis[J]. Practical Pharmacy and Clinical Remedies, 2011, 14(3): 200-202 | |
| Authors: | MENG Qing-ping WANG Jia-jun FENG Juan JIAO Yan-ling PAN Yue |
| Affiliation: | MENG Qing-ping1,WANG Jia-jun2,FENG Juan1,JIAO Yan-ling3,PAN Yue4(1.Department of Neurology,Shengjing Hospital of China Medical University,Shenyang 110004,China,2.China Medical University,Shenyang 110001,3.Central Hospital of Jinzhou,Jinzhou 121000,4.Weikang Hospital of Shenyang,Shenyang 110021,China) |
| Abstract: | Objective To explore the effect of immunoglobulin with hormone treatment for multiple sclerosis.Methods 41 cases of MS patients were divide into 2 groups:treatment group with immunoglobulin plus hormone(20 cases)and control group with hormone alone(21cases).Each group received hormone while treatment group with immunoglobulin plus hormone received 0.4 g/kg immunoglobulin every day for 5 d intravenously.All clinical and immunological variables were measured at the baseline and 3 weeks after hormone therapy.R... |
| Keywords: | Multiple sclerosis Hormone Immunoglobulin |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |