自体造血干细胞移植治疗恶性血液病

为探讨恶性血液病的有效治疗方法,应用自体骨髓移植(ABMT)38例,自体外周血造血干细胞移植(ABSCT)13例,自体外周血造血干细胞与自体骨髓联合移植15例。治疗白血病54例,恶性淋巴瘤11例,多发性骨髓瘤1例。外周血造血干细胞采用化疗加多抗甲素或C—CSF动员。移植物采用微波、阿克拉霉素净化处理。结果:两组动员方案均有良好动员效果。ABSCT组及联合移植组造血功能恢复比ABMT组快(P<0.05),合并症少。66例中,45例仍呈持续缓解(CCR),中位CCR时间32(5～98)个月,复发21例。3年无病生存率及复发率分别为68.5％及26.1％。结果表明:自体造血干细胞移植是根治恶性血液病的有效手段。ABSCT及联合移植具有造血功能恢复快,合并症少等优点。微波和阿克拉霉素体外净化移植物是一种简便、有效的净化方法。

AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR MALIGNANT HEMATOLOGICAL DISEASES

In an attempt to explore the treatment for malignant hematological diseases by autolo-gous hematopoietic stem cells, it was performed 38 cases of autologous bone marrow transplation (ABMT), 13 ones of autologous peripheral blood stem cell transplantation (ABSCT) and 15 ones of peripheral blood stern cells (PBSC) combined ABMT. These 66 cases included 54 leukemia, 11 malignant lymphadenoma and 1 multiple myeloma. All of graft were purged by microwave and/or aclarubicin. The results showed that hematopoietic function of ABSCT group and combined group recovered faster than that of ABMT group, and the former two groups had fewer complications than ABMT group. 45 of 66 cases were in constant complete remission (CCR). The medium CCR time was 32 months (5-98 months), but the other 21 cases had a relapse. Three year disease -free survial rate was 68. 5% and relapse rate was 26.1%. It is considered that ABSCT and PBSC combined ABMT have many benefits, such as faster hematopoiesis and fewer complications. They are the effective therapies for malignant hematolcgical diseases.