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Manufacture of strontium-82/rubidium-82 generators and quality control of rubidium-82 chloride for myocardial perfusion imaging in patients using positron emission tomography |
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| Authors: | Teresa M. Alvarez-Diez Robert deKemp Robert Beanlands John Vincent |
| Affiliation: | a Nuclear Medicine Division, Ottawa Civic Hospital, 1053 Carling Ave., Ottowa, Ont., Canada K1Y 4E9 b Ottawa Heart Institute, 1053 Carling Ave., Ottowa, Ont., Canada K1Y 4E9 c TRIUMF, 4004 Westbrook Mall, Vancouver, B.C., Canada V6T 2A3 |
| Abstract: | We describe a protocol to manufacture 82Sr/82Rb generators and 82RbCl for myocardial imaging with PET. The generators are manufactured in 3 stages: (1) preparation of a tin oxide column, (2) leak test of the generator column and (3) loading of the generator with 82Sr. The generators produced sterile and non-pyrogenic 82RbCl for i.v. injection. No significant 82Sr/85Sr breakthroughs were observed after elution with 20 l of saline. The automated system delivered human doses of 82RbCl accurately. |
| Keywords: | coronary artery disease heart muscle perfusion positron emission tomography rubidium 82 strontium 82 |
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