咪唑斯汀联合赛庚啶递减疗法治疗慢性荨麻疹临床研究

目的：探讨咪唑斯汀联合赛庚啶递减疗法治疗慢性荨麻疹的临床疗效。方法：将178例慢性荨麻疹患者随机分为两组，对照组予常规咪唑斯汀治疗，观察组予咪唑斯汀联合赛庚啶递减疗法治疗，观察两组疗效、不良反应、复发率及血清IgE的变化。结果：治疗结束后观察组与对照组痊愈率分别为75．28％、61．79％，总有效率分别为93．26％、83．15％，观察组均明显高于对照组，差异有统计学意义（P＜0．05）；两组患者治疗后血清IgE水平均较治疗前显著下降，且观察组明显低于对照组水平，差异有统计学意义（ P＜0．05）；观察组不良反应发生率为13．43％，对照组为9．09％，两组不良反应发生率无统计学差异（P＞0．05）；观察组复发率为4．49％，对照组为15．73％，观察组复发率明显低于对照组，差异有统计学意义（ P＜0．05）。结论：咪唑斯汀联合赛庚啶递减疗法治疗慢性荨麻疹临床疗效好，且无明显不良反应及复发率低等优点，值得临床推广应用。

Clinical Study of Mizolastine Combined with Cyproheptadine Decreasing Therapy on Chronic Urticaria

Objective： To explore the effect of mizolastine combined with cyproheptadine decreasing therapy on chronic urticaria .Method： 178 patients with chronic urticaria were randomly divided into two groups , the control group received conventional mizolastine treatment ,and the observation group treated by mizolastine combined with cyproheptadine decreasing therapy , and the effects , adverse reactions and serum IgE changed were observed .Result：After the end of treatment , the cure rate in the observation group and control group was 75.28%and 61.79%respectively, the total effective rate was 93.26%and 83.15%,and those in the observation group were significantly higher difference （P＆lt;0.05）.The serum IgE levels in both groups were decreased significantly than before treatment , and the observation group was significantly lower than the control group ,There＆#39;s statistically significant （ P＆lt;0.05） .The incidence of adverse reactions was 13. 43%and 9.09%, and there were no significant difference （ P＆gt;0.05 ）; The recurrence rate in observation group was 4.49%,and that was significantly lower than the control group which was 15.73%（P＆lt;0.05）. Conclusion：The mizolastine combined with cyproheptadine decreasing therapy on chronic urticaria are effi -cacy and with low recurrence rate , and no significant adverse reactions .