| 内毒素休克血浆一氧化氮的变化及其意义 |
| |
| 引用本文： | 冯刚,蒋健,惠小平,喻中诚,史以珏.内毒素休克血浆一氧化氮的变化及其意义[J].中华急诊医学杂志,1997(1). |
| |
| 作者姓名： | 冯刚 蒋健 惠小平 喻中诚 史以珏 |
| |
| 作者单位： | 湖北省十堰市东风汽车公司中心医院急诊科 湖北十堰442008
(冯刚)，上海瑞金医院急诊科 上海200025
(蒋健，惠小平，喻中诚)，上海瑞金医院急诊科 上海200025(史以珏) |
| |
| 摘 要： | 为了探讨一氧比氮与内毒素休克的关系,应用脂多糖建立兔内毒素休克模型,然后应用N-哨基左旋精氨酸治疗,分别观察治疗前后血压,血浆NO的变化.结果发现内毒素休克时,血浆NO浓度升高,静注L-NNA后,休克大白兔血压升高,血浆NO下降.提示内毒素休克时,机体内NO产生增加并与低血压有关,L-NNA可能具有治疗内毒素休克的意义,值得进一步研究.
|
| 关 键 词： | 内毒素休克 一氧化氮 N—硝基左旋精氨酸 |
ALTERATION AND SIGNIFICANCE OF NITRIC OXIDE IN ENDOTOXIC SHOCK |
| |
| Feng Gang,Jiang Jian,Hui Xiaoping,et al..ALTERATION AND SIGNIFICANCE OF NITRIC OXIDE IN ENDOTOXIC SHOCK[J].Chinese Journal of Emergency Medicine,1997(1). |
| |
| Authors: | Feng Gang Jiang Jian Hui Xiaoping |
| |
| Institution: | Feng Gang,Jiang Jian,Hui Xiaoping,et al.Emergency Department of Central Hospital of Dong Feng Motor Company,Shiyan,Hubei,442008 |
| |
| Abstract: | To investigate the correlation between nitric oxide (NO) and endotoxic shock, endotoxic shock model of rabbits were made by infusing LPS.and then treated them by infusing Nw-nitro-L-arginine (L-NNA), and observed the blood pressure, NO before and after treatment. I he results showed that the decrease of blood pressure associated with elevation of plasma NO during rabbits in endotoxic shock could be influenced by infusion of L-NNA. which will lead to the elevation of the blood pressure. It suggested that the excessive production of NO in endotoxic shock could be related to the decrease of blood pressure and the L-NNA would be of value in treating endotoxic shock. |
| |
| Keywords: | Endotoxic shock Nitric oxide Nw-nitro-L-arginine |
| 本文献已被 CNKI 等数据库收录！ |
|
