| DNA甲基化与肺癌 |
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| 引用本文： | 陶文虎,于在诚.DNA甲基化与肺癌[J].癌症进展,2007,5(4):380-384,389. |
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| 作者姓名： | 陶文虎 于在诚 |
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| 作者单位： | 安徽医科大学第一附属医院胸外科,安徽,合肥,230022;安徽医科大学第一附属医院胸外科,安徽,合肥,230022 |
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| 基金项目： | 国家自然科学基金资助项目(NO.30471427) |
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| 摘 要： | DNA异常甲基化是人类肿瘤中常见的改变。发生在启动子区的CpG岛的异常甲基化是基因失活的最常见机制。某些基因甲基化与肺癌发生密切相关,且是肺癌发生中的早期事件。
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| 关 键 词： | 肺肿瘤 甲基化 CpG岛 |
DNA methylation in lung cancer |
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| Tao Wenhu,Yu Zaicheng.DNA methylation in lung cancer[J].Oncology Progress,2007,5(4):380-384,389. |
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| Authors: | Tao Wenhu Yu Zaicheng |
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| Abstract: | Aberrant methylation of DNA has been recognized as common changes in human cancers. Aberrant methylation of CpG islands,which are located in or near the promoter region of many genes,is the most common mechanism to inactivate genes. The methylation in some genes is strongly associated with lung cancer,and the methylation was occurring as a preneoplastic change in lung cancer. |
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| Keywords: | lung neoplasms methylation CpG islands |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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