| 干扰素治疗慢性乙型肝炎应答的因素探讨 |
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| 引用本文： | 高敏 过建春. 干扰素治疗慢性乙型肝炎应答的因素探讨[J]. 中西医结合肝病杂志, 1997, 7(2): 78-80 |
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| 作者姓名： | 高敏 过建春 |
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| 作者单位： | 浙江医科大学附属邵逸夫医院消化科，杭州市第六人民医院，杭州市第六人民医院，杭州市第六人民医院 310016 |
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| 摘 要： | 目的:总结干扰素治疗慢性乙型肝炎的应答因素。方法:应用干扰素α-2b 300万u肌注,每天1次,连续3天,以后隔天1次,疗程3个月,治疗慢性乙型肝炎162例。结果:干扰素应答者78例,非应答者84例,应答率为48％。结论:干扰素治疗慢性乙型肝炎,对年轻、感染时间短、非母婴感染特别是有明确输血史者疗效较好:对抗-HBe阳性者疗效欠佳;其治疗过程中ALT正常与否可作为干扰素疗效的预测因素。
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| 关 键 词： | 干扰素 慢性乙型肝炎 应答因素 |
A Study about Resposive Factors for Interferon Treating Chronic Hepatitis B |
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| Gao Min,Guo Jianchum,Chen Sulian,Tu ShixingDepartment Gastroenterology,Affiliated Hospital ofZhejian Medical University,Hong Zhou. A Study about Resposive Factors for Interferon Treating Chronic Hepatitis B[J]. Chinese Journal of Integrated Traditonal and Western Medicine on Liver Diseases, 1997, 7(2): 78-80 |
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| Authors: | Gao Min Guo Jianchum Chen Sulian Tu ShixingDepartment Gastroenterology Affiliated Hospital ofZhejian Medical University Hong Zhou |
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| Abstract: | Aim:To investigate the responsive factors for the treatment of chronic hepatitis B (CHB) with Interferon(Ifn). Method: 162 CHB patients were treated with IFN for three months and observed before and after treatment. Result:78 patients made response to IFN, 84 no response, the responsive rate was 48%. Compared with irresponsive patient, the responsive were younger ages, shorter infectious time, fewer coimfection between mother and infant, more with blood tranfusion, less anti-HBe positively and less ALT repeatedly (all of P<0. 01). Conclusion: Effects of IFN on CHB are associated with patient ages,disease history and infectious manner, etc. ,while ALT activity can by regarded as a forecasting factor for IFN effect. |
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| Keywords: | Interferon Chronic Hepatitis B Responsive Factors |
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