转移性非小细胞肺癌患者不同生存期预后分析 |
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引用本文: | 史国栋,徐裕金,孙晓江,狄小云,单国平.转移性非小细胞肺癌患者不同生存期预后分析[J].中国现代医生,2013,51(19):10-12,51. |
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作者姓名: | 史国栋 徐裕金 孙晓江 狄小云 单国平 |
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作者单位: | 浙江省肿瘤医院放疗科,浙江杭州,310022 |
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摘 要: | 目的 通过比较晚期非小细胞肺癌不同生存期的患者一般特征,分析影响晚期非小细胞肺癌的长期生存的因素.方法 回顾性分析浙江省肿瘤医院2005~2010年初诊为晚期非小细胞肺癌的251例患者.对生存期<6个月与生存期>2年的两组患者年龄、性别、吸烟、病理分型、治疗方法、TN分期、转移部位数、PS评分、是否脑转移、并发症等方面进行Logistic回归分析.应用Kaplan-Meier法及Log-rank检验进行生存比较.COX多因素分析对全组251例患者进行多因素分析.结果 251例患者中位生存时间为10.48个月,1年生存率、2年生存率、5年生存率分别为17.53%、10.4%、2.79%.共44例(17.53%)患者生存期超过2年,其中超过5年的患者为7例(2.79%),74例(29.48%)患者生存期短于6个月.生存期<6个月与>2年的患者在性别、病理、治疗方法、N分期、转移部位数、PS评分、脑转移方面差异具有显著性.COX多因素分析显示,淋巴结转移为NO或N1 (P=0.000),PS评分为0~1(P=0.000),多学科治疗(P=0.01),单发肺内或骨转移(P=0.00),非吸烟(P=0.019)是患者长期生存的有利因素.结论 淋巴结转移为N0或N1、PS评分为0~1、单一肺内或骨转移、接受多种治疗方法、女性、腺癌可能作为预测晚期非小细胞肺癌长期生存的因素.
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关 键 词: | 非小细胞肺癌 转移性 长期生存 预后因素 |
The prognosis factors in advanced non-small cell lung cancer patients |
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Authors: | SHI Guodong XU Yujin SUN Xiaojiang DI Xiaoyun SHAN Guoping |
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Institution: | (Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou 310022, China) |
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Abstract: | Objective To compare the difference between long term survivors(LST) and non-LST. To evaluate the rea- son which influence advanced non-small lung cancerpatients. Methods A total of 251 patients with advanced non- small lung cancer from 2005 to 2010 was reviewed.Compared the two arms with age, sex, smoking, pathology, ther- apy method, T tagging, N staging, performance status, brain metastasis and compliacations with logistic. The survival curves for all patients were estimated according to the Kaplan-Meier method. A multivariate analysis of the clinical factors for 251 patients. Results The MST 1-year, 2-year and 5-year survival rates for 251 patients was 10.48 months, 17.6%, 10.4%, 3.79%. there were 44 cases who survivor more than 2 years and 74 less than 6 months ,7 cases were more than 5 years. The age,sex,pathology therapy method, T staging,N staging, performance status,brain metastasis metastasis were different between the LTS and non-LTS. The good factors by COX regression model for these 251 patients with lung metastasises was found to be carrelated with early N, good PS,muhitherapy,single bone or lung metastasis, EGFR-TKI therapy and non-smoking. Conclusion Good PS, adnocarcinomas, female, single lung or bone metastasis, muhitherapy and early N may predict the long term surviors as factors. |
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Keywords: | Non-small cell lung cancer Metastasis Longterm survival Prognosis factors |
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