EV71感染手足口病患儿细胞及体液免疫功能研究 |
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引用本文: | 张海瑛,韩宜姚.EV71感染手足口病患儿细胞及体液免疫功能研究[J].中国现代医生,2013(9):28-30. |
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作者姓名: | 张海瑛 韩宜姚 |
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作者单位: | 浙江省舟山医院妇幼保健院区儿科,浙江舟山316000 |
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基金项目: | 浙江省舟山市科技局立项资助项目(2011C13046) |
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摘 要: | 目的探讨EV71感染手足口病患儿细胞免疫及体液免疫功能变化。方法将92例EV71感染的手足口病患儿分为重型组、轻型组,另选正常健康对照组儿童30例为对照组,检测各组静脉血T细胞亚群、B细胞表达情况,免疫球蛋白及补体C3、C4水平及TNF-α、IL-6及IL-10水平。结果重型组及轻型组患儿Th及Ts细胞比例降低,B细胞比例升高,TNF-α、IL-6、IL-10水平升高,IgA、IgG、C3、C4水平升高,各组间差异有统计学意义。结论 EV71感染手足口病患儿存在细胞及体液免疫异常情况,并且同病情相关,临床检测有助于病情预测及预后评估。
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关 键 词: | 肠道病毒71 手足口病 细胞免疫 体液免疫 免疫球蛋白 |
Study of cell immunity and humoral immunity in HFMD infants with EV71 infection |
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Authors: | ZHANG Haiying HAN Yiyao |
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Institution: | ZHA NG Haiying HA N Yiyao (Department of Paediatrics, Maternal and Child Endemic Area of Zhoushan Hospital in Zhejiang Province, Zhoushan 316000, China) |
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Abstract: | Objective To investigate the change of cell immune and humoral immunity in hand foot and mouth disease (HFMD) with EV71 infection. Methods A total of 92 cases of children patients with HFMD were selected and divided into severe groups and mild groups, then chose healthy children 50 cases as control group, expression of T and B cell were detected, expression level of immunoglobulin, addiment C3, addiment C4, TNF-, IL-6 and IL-IO were detected. Results Expressive rate of Th and Ts was decreased and expressive rate of B was increased, level of TNF-, IL-6 and IL-10 in serum were increased and level of IgA, IgG, C3 and C4 were increased in severe groups and mild groups, and there was a difference along every groups. Conclusion Cell immune and humoral immunity were preternatural in HFMD with EV71 infection, and related to pathogenetic condition, and detecting it's helpful for pretesting pathogenet- ic condition and evaluate prognosis. |
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Keywords: | Enterovirus 71 HFMD Cell immunity Humoral immunity Immunoglobulin |
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