EV71感染手足口病患儿细胞及体液免疫功能研究

目的探讨EV71感染手足口病患儿细胞免疫及体液免疫功能变化。方法将92例EV71感染的手足口病患儿分为重型组、轻型组,另选正常健康对照组儿童30例为对照组,检测各组静脉血T细胞亚群、B细胞表达情况,免疫球蛋白及补体C3、C4水平及TNF-α、IL-6及IL-10水平。结果重型组及轻型组患儿Th及Ts细胞比例降低,B细胞比例升高,TNF-α、IL-6、IL-10水平升高,IgA、IgG、C3、C4水平升高,各组间差异有统计学意义。结论 EV71感染手足口病患儿存在细胞及体液免疫异常情况,并且同病情相关,临床检测有助于病情预测及预后评估。

Study of cell immunity and humoral immunity in HFMD infants with EV71 infection

Objective To investigate the change of cell immune and humoral immunity in hand foot and mouth disease （HFMD） with EV71 infection. Methods A total of 92 cases of children patients with HFMD were selected and divided into severe groups and mild groups, then chose healthy children 50 cases as control group, expression of T and B cell were detected, expression level of immunoglobulin, addiment C3, addiment C4, TNF-, IL-6 and IL-IO were detected. Results Expressive rate of Th and Ts was decreased and expressive rate of B was increased, level of TNF-, IL-6 and IL-10 in serum were increased and level of IgA, IgG, C3 and C4 were increased in severe groups and mild groups, and there was a difference along every groups. Conclusion Cell immune and humoral immunity were preternatural in HFMD with EV71 infection, and related to pathogenetic condition, and detecting it＇s helpful for pretesting pathogenet- ic condition and evaluate prognosis.