舒血宁注射液对不稳定型心绞痛患者血清BNP、hs-CRP和颈动脉粥样硬化斑块的影响

目的评价舒血宁注射液对不稳定型心绞痛患者血清脑钠肽（BNP）、高敏C反应蛋白（hs—CRP）和颈动脉粥样硬化斑块的影响。方法100例不稳定型心绞痛患者，随机分成观察组和对照组两组。对照组采用常规用药：观察组在对照组治疗方式的基础上，加用舒血宁注射液治疗。结果治疗两周后，观察组总有效率为90．00％高于对照组总有效率72．00％，具有显著性差异（P〈0．05）。治疗两周后，观察组的血清BNP及hs—CRP为（77.2±23．9）ng／L、（6．0±2．9）mg／L均低于对照组血清BNP（101．4±22．5）ng／L、hs—CRP（9．5±3．4）mg／L，差异均有统计学意义（P〈0．01）。治疗两周后，观察组斑块大小、斑块厚度及IMT分别为（0．06±0．01）cm^2、（1．84±0．46）mm、（1．29±0．64）mm均低于对照组斑块大小（0．07±0．02）cm^2、斑块厚度（2．02_-q）．41）mm及IMT（1．58±0．62）mm，差异有统计学意义（P〈0．05）。结论舒血宁注射液用于治疗不稳定型心绞痛患者疗效可靠，不但能有效改善不稳定型心绞痛患者的血清BNP、hs—CRP水平，还能明显改善患者的斑块大小及斑块厚度，对不稳定型心绞痛具有一定的阻断和逆转作用。

Study on Shuxuening injection intervention of serum BNP,hs-CRP and carotid atherosclerosis plaque in patients with unstable angina pectoris

Objective To study the effect of Shuxuening Injection intervention serum BNP,hs-CRP and carotid atherosclerosis in patients with unstable angina pectoris. Methods In 100 patients with unstable angina patients, randomLy divided into observation group and control group two groups. The control group was treated with routine medication. The observation group combined with Shuxuening injection on the basis of the control group treatment methods. Results After two weeks of treatment, the observation group the total effective rate was 90% higher than that of the control group,the total efficiency of 72%,with significant difference （P〈 0.05）. After two weeks of treatment,the serum levels of BNP and hs-CRP,patients in the observation group was （77.2±23.9）ng/L, （6.0±2.9） mg/L are lower than those of the control group （101.4±22.5） ng/L, （9.5±3.4） mg/L,the differences were statistically significant （P 〈 0.01）. After two weeks of treatment,plaque size,thickness and IMT,patients in the observation group was （0.06±0.01 ） cm^2, （1.84±0.46） mm, （1.29±0.64） mm are lower than those of the control group （0.07±0.02） cm^2, （2.02±0.41） mm, （1.58±0.62）mm,there are statistically significant differences （P 〈 0.05）. Conclusion Shuxuening injection for the treatment of patients with unstable angina pectoris is reliable,not only can effectively improve the patients with unstable angina pectoris of serum BNP,hs-CRP levels,can significantly improve the plaque size and the thickness of plaque in patients,with reversal and the effect in the treatment of unstable angina pectoris.