腹腔镜术后加用米非司酮与内美通治疗子宫内膜异位症的临床效果比较

目的 探讨子宫内膜异位症患者采用腹腔镜后加用米非司酮与内美通治疗的临床效果.方法 回顾性分析2010年5月～2012年5月来我院进行腹腔镜治疗的子宫内膜异位症患者225例,将其按照治疗方法分为米非司酮组、内美通组及对照组各75例,分别口服米非司酮、内美通及不实施任何干预措施,对三组的治疗效果及副反应情况进行比较.结果 米非司酮组及内美通组患者的治疗有效率与对照组比较明显较高,复发率明显较低,月经复潮时间明显较短,差异均具有显著性(P＜0.05).米非司酮组患者的治疗有效率、复发率、完全闭经的患者所占的比例及月经复潮时间与内美通组比较差异不具有显著性(P＞0.05)；内美通组患者的副反应发生率与米非司酮组、对照组比较明显较高,差异具有显著性(P＜0.05).结论 子宫内膜异位症患者在腹腔镜治疗的基础上口服米非司酮及内美通能够收到较为满意的近期疗效,但米非司酮具有相对较小的副反应,可以作为首选药物治疗子宫内膜异位症并在临床广泛的推广应用.

Clinical effect of endometriosis patients treated with mifepristone and gestrinone after laparoscopic surgery

Objective To explore the clinical effects of endometriosis patients laparoscopic surgery treated with mifepristone and gestrinone. Methods A total of 225 cases with laparoscopic treatment of endometriosis were selected form May 2010 to May 2012 in our hospital, they were divided into the mifepristone group, the gestrinone group and control group, there were 75 cases in each group, they were treated with mifepristone, gestrinone, without any inter- vention measures, the therapeutic effect and side-effect profile in three groups were compared. Results The efficient in the mifepristone group and the gestrinone group were higher than the control group, the relapse rate was significant- ly lower, the time of menstruation was significantly shorter, there were significant differences （P 〈 0.05）. There were no significant differences in the efficient treatment, the recurrence rhte, the proportion of patients fully amenorrhea and menstruation time between the mifepristone group and the gestrinone group （P 〉 0.05）. The incidence of side effects in the gestrinone group was significantly higher than the mifepristone group and the control group, there were signifi- cant difference （P 〈 0.05）. Conclusion Endometriosis patients in the laparoscopic treatment on the basis of oral mifepris tone and the gestrinone is able to receive more satisfied with the short-term effect, but has relatively smaU side effects of mifepristone can be used as the drug of choice for treatment endometriosis and widely used in clinical application.