单剂量静脉注射用人血丙种球蛋白治疗新生儿ABO溶血病的疗效观察

目的探讨单次剂量丙种球蛋白（IVIG）治疗新生儿ABO溶血病的临床疗效。方法选择2007年1月～2012年2月在我院新生儿科住院诊断为新生儿ABO溶血病患儿76例，均给予常规治疗，中剂量组39例，加用单剂丙种球蛋白0．5g/kg；大剂量组37例，加用单剂丙种球蛋白1．0g/kg，对两组患儿的疗效进行对比分析。结果两组患儿治疗前以及治疗后24h、48h、72h胆红素值比较，差异无统计学意义（P〉0．05）；两组患儿游离抗体试验转阴率、需要换血人数、胆红素脑病发生人数、听力筛查通过率和住院天数比较，差异无统计学意义（P〉0．05）。结论单次大剂量IVIG治疗新生儿ABO溶血病与中剂量IVIG疗效相当。

The therapeutic effects of single dose of intravenous immunoglobulin on newborn infants with ABO hemolytic disease

Objective To invesgate the therapeutic effects of single dose of intravenous immunoglobulin （IVIG） on newborn infants with ABO hemolytic disease. Methods From Jan 2007 to Feb 2012 in Sanming first hospital affiliated to fujian medical university,76 newborn infants with ABO hemolytic disease were given conventional treatment. The middle dose group of 39 cases, with a single dose of IVIG in 0.5 g/kg; high dose group 37 cases, with single dose of IVIG in 1.0 g/kg, compared the curative effect of two groups of children. Results Treatment of two groups before and after treatment in 24 hours, 48 hours, 72 hours of bilirubin value comparison, no significant difference statistically（P 〉 0.05）;Two groups of children with free antibody test negative rate, the number of blood transfusion,the number of bilirubin encephalopathy, hearing screening pass rate and the length of hospitalization were compared,no significant difference statistically（P 〉 0.05）. Conclusion A single large dose of IVIG in the treatment of ABO hemolytic disease of the newborn and middle dose of IVIG have the same effect.