欣母沛与米索前列醇预防高危孕妇剖宫产术后产后出血的效果比较

目的 探讨欣母沛与米索前列醇用于预防剖官产术高危孕妇产后出血的临床效果.方法 选择有产后出血倾向的孕产妇100例为研究对象,随机分为欣母沛组和米索前列醇组各50例.欣母沛组产后在静滴催产素的基础上加用欣母沛肌肉注射；米索前列醇组在静滴催产素的基础上加用米索前列醇舌下含服.统计两组产后2h、24h出血量、产后出血的发生率、药物的不良反应情况.结果 产后2h和24 h欣母沛组的出血量为(228.7±42.9)mL和(286.6±71.4) mL,米索前列醇组为(352.5±51.7)mL和(396.3±75.9)mL,欣母沛组显著低于米索前列醇组(P＜0.01).欣母沛组产后出血率为8％,米索前列醇组产后出血率为44％,欣母沛组显著低于米索前列醇组(P＜0.01).结论 欣母沛用于预防高危孕妇产后出血具有较好的效果,且与米索前列醇相比,不增加不良反应,值得在临床推广.

Comparison of clinical efficacy of hemabate and misoprostol for prevent- ing postpartum hemorrhage

Objective To discuss clinical efficacy of hemabate and misoprostol for preventing postpartum hemorrhage. Methods A total of 100 cases with postpartum hemorrhage were divided into hemabate group and misoprostol group. Hemabate group was treated by hemabate based on normal treatment. Misoprostol group was treated by mlsoprostol based on normal treatment. Amount of bleeding,occurrence rate, adverse reaction of two groups were compared. Results Amount of bleeding of hemabate group was （228.7±42.9）mL and （286.6±71.4）mL at 2 h and 24 h after delivery, and misoprostol group was （352.5±51.7）mL and （396.3±75.9）mL, which were higher than hemabate group （P 〈 0.01 ）. Postpartum hemorrhage rate of hemabate group was 8%, and misoprostol group was 44%. Hemabate group was lower than misoprostol group （P 〈 0.01 ）. Conclusion Hemabate for preventing postpartum hemorrhage shows good efficacy. Compared to misoprostol, hemabate has no more adverse reaction.