| 贝那普利联合前列腺素E1治疗糖尿病肾病的临床疗效观察 |
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| 引用本文： | 朱涛.贝那普利联合前列腺素E1治疗糖尿病肾病的临床疗效观察[J].中国现代医生,2013(9):50-51. |
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| 作者姓名： | 朱涛 |
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| 作者单位： | 湖南省双峰县中医医院内科,湖南双峰417700 |
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| 摘 要： | 目的观察贝那普利联合前列腺素E1治疗糖尿病肾病的临床疗效。方法收集临床确诊的50例糖尿病肾病患者随机分为联合用药组（n=25）和贝那普利组（n=25），观察两组治疗前后尿蛋白及肾功能的变化。结果联合用药组在治疗4周后，24h尿蛋白定量及尿微自蛋白排泄率即出现明显下降（P〈0．05）。两组患者在治疗8周后24h尿蛋白定量及尿微白蛋白排泄率均较治疗前明显下降（P〈0．05），但联合用药组较贝那普利组下降更为明显（P〈0．05）。结论贝那普利联合前列腺素E1治疗糖尿病肾病效果明显，值得临床进一步推广使用。
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| 关 键 词： | 糖尿病肾病 贝那普利 前列腺素E1 蛋白尿 |
Clinical efficacy of benazepril combined with prostaglandin El for the treatment of diabetic nephropathy |
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| Authors: | ZHU Tao |
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| Institution: | ZHU Tao (Medical Department, the Chinese Medicine Hosptial of Shuangfeng, Shuangfeng 417700, China) |
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| Abstract: | Objective To observe clinical efficacy of benazepril combined with prostagIandin E1 on treating diabetic nephropathy （DN）. Methods A total of 50 patients with DN were enrolled and randomLy divided into combination treatment group（n = 25） and benazepril treatment group （n = 25）, and the changes of urine protein and renal function were observed. Results After 4 weeks treatment, 24 h urine protein level and 24 h urinary microalbumin excretive rate of combination treatment group were significantly decreased than that before treatment（P 〈 0.05）. After 8 weeks treatment,24 h urine protein level and 24 h urinary microalbumin excretive rate of two groups were significantly decreased than that before treatment（P 〈 0.05）,and the combination treatment group were decreased more significantly than benazepril treatment group（P 〈 0.05）. Conclusion Benazepril combined with prostaglandin E1 treatment is an ideal treatment for DN and worthy of clinical use. |
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| Keywords: | Diabetic nephropathy Benazepril Prostaglandin E 1 Proteinnria |
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