聚乳酸防粘连凝胶及透明质酸钠预防术后肠粘连效果的对比分析

目的对比观察聚乳酸防粘连凝胶和透明质酸钠在预防腹部术后肠粘连的临床疗效，以指导临床用药。方法根据患者选择抗粘连药物的不同，将患者分为聚乳酸防粘连凝胶组和透明质酸钠组，手术结束关腹前，分别涂以聚乳酸防粘连凝胶或透明质酸钠，观察术后患者体温恢复正常所需时间、肠管通气时间以及术后6个月肠粘连的表现。结果所有患者中，术后均未出现药物过敏现象，并且无不适症状，无脓肿、肠瘘及其他不良反应，术后改善情况良好。观察术后1周患者的各项恢复情况如发热时间、肠鸣音恢复时间、肛门排气时间，聚乳酸防粘连凝胶组显著优于透明质酸钠组，差异有统计学意义（P〈0．05）。聚乳酸防粘连凝胶组在术后3个月和术后6个月发生肠粘连表现的患者例数显著少于透明质酸钠组，差异有统计学意义（P〈0．05）。结论聚乳酸防粘连凝胶和透明质酸钠对腹部手术后预防肠粘连均有明显作用，聚乳酸防粘连凝胶预防粘连效果优于透明质酸钠。

The effects of polylactic acid gelcombined with sodium hyaluronate in the prevention of postoperative ankylenteron

Objective To compare the effects of polylactic acid gel with sodium hyaluronate in the prevention of postoperative ankylenteron, to explore the clinical strategy. Methods According to the selection of patients with anti adhesion drug is different, the patients were randomly divided into polylactic acid gel group and sodium hyaluronate group, completed in operation before closing abdomen, are coated with polylactic acid gel or hyaluronic acid sodium, observation of postoperative patients with restoration of normal temperature time required, intestine ventilation time and after 6 months of intestinal adhesion performance. Results In all patients, postoperative were found drug allergies, and no discomfort symptoms, without abscess, fistula and other adverse reactions, postoperative improvement in good condition. Observation of postoperative 1 weeks in patients with various recovery： such as the heating time, borborygmus recovery time, anal exhaust time, poly lactic acid anti-adhesion gel group was significantly better than that of sodium hyaluronate group, the difference was statistically significant （P 〈 0.05）. Poly lactic acid anti-adhesion gel group in 3 months after operation and postoperative 6 months of intestinal adhesion performance of the number of patients was significantly less than the sodium hyaluronate group, the difference was statistically significant （P 〈 0.05）. Conclusion Poly lactic acid gel and sodium hyaluronate on preventing postoperative intestinal adhesions have obvious effects, polylactic acid anti-adhesion gel adhesion prevention effect is better than that of sodium hyaluronate.