144例COVID-19患者实验室部分检测指标与病情严重程度的关系

目的 分析新型冠状病毒肺炎(COVID-19)患者实验室部分指标与病情严重程度的关系.方法 收集2020年1月—3月武汉大学中南医院COVID-19患者实验室检查结果,比较COVID-19轻型及普通型(普通组)和重型及危重型(重症组)患者血常规、D-二聚体(DD)、C-反应蛋白(CRP)、降钙素原(PCT)、血清淀粉样...

Correlation between some laboratory indexes and severity of COVID-19 in 144 patients

Objective To study the correlation between some laboratory indexes and severity of corona virus disease 2019(COVID-19).Methods The results of laboratory examination of 144 patients with COVID-19 confirmed in Zhongnan Hospital of Wuhan University from January 20,2020 to March 10,2020 were collected and analyzed retrospectively.The blood routine examination,D-dimer(DD),C-reactive protein(CRP),procalcitonin(PCT),serum amyloid A protein(SAA),cytokines and lymphocyte subgroups were compared between common and severe COVID-19 patients.Logistic regression was used to analyze the relationship between laboratory indexes and COVID-19 severity.Results Severe patients had higher levels of white blood cell(WBC)count,neutrophil percentage(NEUT%),neutrophil/lymphocyte ratio(NLR),SAA,CRP,PCT,DD,interleukin(IL)-6 and IL-10 than commonpatients(P<0.05).Lymphocyte percentage(LYMPH%)was significantly lower in severe group than that in common group(P<0.05).There was no significant difference in mean corpuscular volume(MCV),red blood cell volume distribution width(RDW),hemoglobin(Hb),platelet(PLT)count,tumor necrosis factor alpha(TNF-α),IL-2 or IL-4 between the two groups(P>0.05).The total lymphocyte number was significantly lower in severe group than that in common group(P<0.05),but no significant difference was found in the lymphocyte constituent ratio between the two groups(P>0.05).Logistic regression analysis showed that WBC count,NEUT%,NLR,SAA,DD,CRP,IL-6 and IL-10 could be used as laboratory indexes to reflect the severity of COVID-19(P<0.05).Conclusion WBC count,NEUT%,NLR,SAA,DD,CRP,IL-6 and IL-10 in severe COVID-19 patients have obvious changes as compared with those in common patients.The changes of these laboratory indexes are helpful for the early diagnosis of COVID-19.