| 甲泼尼龙片对老年间质性肺疾病患者的影响 |
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| 引用本文： | 沈波,张浩,毛爽,王立斌,李雪薇. 甲泼尼龙片对老年间质性肺疾病患者的影响[J]. 实用临床医药杂志, 2021, 25(3): 69-72. DOI: 10.7619/jcmp.20200935 |
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| 作者姓名： | 沈波 张浩 毛爽 王立斌 李雪薇 |
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| 作者单位： | 辽宁省沈阳经济技术开发区人民医院内三科,辽宁沈阳,110000;北部战区空军医院呼吸及危重症医学科,辽宁沈阳,110000;东北国际医院皇姑院区呼吸内科,辽宁沈阳,110000;辽宁省人民医院呼吸内科,辽宁沈阳,110000 |
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| 基金项目： | 辽宁省科学技术计划项目 |
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| 摘 要： | 目的 探讨甲泼尼龙片对老年间质性肺疾病患者临床体征、气道重塑及纤维化相关指标的影响.方法 将98例老年间质性肺疾病患者随机分为观察组和对照组,每组49例.对照组予以抗感染、抗纤维化治疗,观察组在对照组基础上予以甲泼尼龙片治疗.比较2组临床疗效、临床症状及体征消失时间、肺功能[用力肺活量(FVC)、第1秒用力呼气容积(F...
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| 关 键 词： | 甲泼尼龙片 间质性肺疾病 临床体征 气道重塑 纤维化 |
Effects of methylprednisolone tablets in elderly patients with interstitial lung disease |
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| SHEN Bo,ZHANG Hao,MAO Shuang,WANG Libin,LI Xuewei. Effects of methylprednisolone tablets in elderly patients with interstitial lung disease[J]. Journal of Clinical Medicine in Practice, 2021, 25(3): 69-72. DOI: 10.7619/jcmp.20200935 |
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| Authors: | SHEN Bo ZHANG Hao MAO Shuang WANG Libin LI Xuewei |
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| Affiliation: | (The Third Department of Internal Medicine,The People′s Hospital of Shenyang Economic and Technological Development Zone,Shenyang,Liaoning,110000;Department of Respiratory and Critical Care Medicine,Air Force Hospital of Northern Theater,Shenyang,Liaoning,110000;Department of Respiratory Medicine,Huanggu Branch of Northeast International Hospital,Shenyang,Liaoning,110000;Department of Respiratory Medicine,Liaoning Provincial People′s Hospital,Shenyang,Liaoning,110000) |
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| Abstract: | Objective To investigate the effects of methylprednylone tablets on clinical signs,airway remodeling and fibrosis in elderly patients with interstitial lung disease.Methods A total of 98 elderly patients with interstitial lung disease were randomly divided into observation group and control group,with 49 cases in each group.The control group was treated with anti-infection and anti-fibrosis therapy,and the observation group was treated with methylprednisolone tablets on the basis of the control group.Clinical curative effect,clinical symptoms and signs disappeared time,lung function[forced vital capacity(FVC),forced expiratory volume in one second(FEV 1),FEV 1/FVC],airway remodeling,as well as fibrosis related index[matrix metalloproteinase-3(MMP-3),tissue inhibitors of metalloproteinase1(TIMP-1),basic fibroblast growth factor(b-FGF),transforming growth factor-β(TGF-β)]and incidence of complications were compared in the two groups.Results The total effective rate of treatment in the observation group was 85.71%,which significantly higher than 67.35%in the control group(P<0.05).The disappearance time of clinical symptoms and signs in the observation group was significantly shorter than that in the control group(P<0.05).After treatment,FVC,FEV 1 and FEV 1/FVC in both groups were significantly increased,and their levels in the observation group were significantly better than those in the control group(P<0.05).The levels of MMP-3 andB-FGF in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Methylprednylone tablets can effectively improve the clinical symptoms as well as signs as well as lung function,and reduce airway remodeling and pulmonary fibrosis in elderly patients with interstitial lung disease. |
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| Keywords: | methylprednisolone tablets interstitial lung disease clinical sign airway remodeling fibrosis |
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