IL-6、CRP和血清过敏原检测对急性荨麻疹的临床价值

目的探讨血清过敏原检测、血清总免疫球蛋白E(IgE)抗体、过敏原特异性(sIgE)抗体、白细胞介素(IL)-6、C反应蛋白(CRP)水平对于急性荨麻疹的临床价值。方法选取2018年6月—2019年12月上海市浦东新区浦南医院75例荨麻疹患者作为研究组,另选取同期75名健康体检者作为对照组,比较2组血清总IgE抗体、sIgE抗体、CRP、IL-6水平对于急性荨麻疹发作期的诊断价值。结果研究组血清总IgE抗体阳性率高于对照组,差异有统计学意义(P<0.05);研究组血清sIgE抗体阳性率高于总IgE抗体,差异有统计学意义(P<0.05);研究组血清CRP、IL-6水平高于对照组,差异有统计学意义(P<0.05);研究组血清IL-6水平与总IgE抗体水平具有一定的相关性(r=0.595,P<0.05)。结论患者血清过敏原检测及CRP、IL-6水平对于急性荨麻疹筛查和诊断均具有一定的临床价值。

Clinical diagnostic value of serum allergen,IL-6 and CRP levels in patients with acute urticaria

Objective To investigate the diagnostic value of serum total immunoglobulin E(IgE)antibody,allergen specific immunoglobulin E(sIgE)antibody,interleukin(IL)-6 and C-reactive protein(CRP)levels in patients with acute urticaria.Methods From June 2018 to December 2019,75 patients with urticarial treated in our hospital were selected as study group,and 75 healthy persons were selected as control group.The diagnostic value of total IgE antibody,sIgE antibody,CRP and IL-6 in acute urticarial were compared between the two groups.Results The positive rate of serum total IgE antibody in the study group was significantly higher than that in the control group(P<0.05).The positive rate of sIgE antibody was significantly higher than that of the total IgE antibody in the study group(P<0.05).The serum CRP and IL-6 levels of the study group were significantly higher than those of the control group(P<0.05).The level of serum IL-6 in the study group was correlated with the level of total IgE antibody(r=0.595,P<0.05).Conclusion The combined detection and comprehensive evaluation of serum total IgE,sIgE,CRP and IL-6 have clinical value for early screening and diagnosis of acute urticaria.