| 桥本甲状腺炎患者血清IL-17、IL-35与维生素D的相关性 |
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| 引用本文： | 柯文才,顾芸霞,刘洁,金小玲. 桥本甲状腺炎患者血清IL-17、IL-35与维生素D的相关性[J]. 检验医学, 2021, 0(2): 181-184 |
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| 作者姓名： | 柯文才 顾芸霞 刘洁 金小玲 |
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| 作者单位： | 上海市第五人民医院检验科;上海健康医学院附属嘉定区中心医院检验科;上海第一康复医院检验科 |
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| 基金项目： | 上海市闵行区科学技术委员会自然科学基金项目(2018MHZ062)。 |
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| 摘 要： | 目的 探讨桥本甲状腺炎(HT)患者血清白细胞介素(IL)-17、IL-35与维生素D的相关性.方法 选取152例HT患者(HT组),按甲状腺激素水平分为甲状腺功能正常组(51例)、亚临床甲状腺功能减退(简称甲减)组(50例)、临床甲减组(51例),以体检健康者50名作为正常对照组.检测所有对象血清游离三碘甲状腺原氨酸(...
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| 关 键 词： | 白细胞介素17 白细胞介素35 维生素D 桥本甲状腺炎 |
The correlation between serum IL-17 and IL-35 and vitamin D in Hashimoto thyroiditis |
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| KE Wencai,GU Yunxia,LIU Jie,JIN Xiaoling. The correlation between serum IL-17 and IL-35 and vitamin D in Hashimoto thyroiditis[J]. Laboratory Medicine, 2021, 0(2): 181-184 |
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| Authors: | KE Wencai GU Yunxia LIU Jie JIN Xiaoling |
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| Affiliation: | (Department of Clinical Laboratory,Shanghai Fifth People's Hospital,Shanghai 200240,China;Department of Clinical Laboratory,Jiading Central Hospital Affiliated to Shanghai Health Medical College,Shanghai 201800,China;Department of Clinical Laboratory,The First Rehabilitation Hospital of Shanghai,Shanghai 200090,China) |
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| Abstract: | Objective To investigate the correlation between serum interleukin(IL)-17 and IL-35 and vitamin D in Hashimoto thyroiditis.Methods A total of 152 HT patients(HT group)were selected and divided into normal thyroid function group(51 cases),subclinical hypothyroidism group(50 cases)and clinical hypothyroidism group(51 cases)according to the thyroid hormone level.Fifty healthy persons were taken as normal control.Serum levels of free triiodothyronine(FT3),free thyroxine(FT4),thyroid stimulating hormone(TSH),thyroid globulin antibody(TgAb),thyroid peroxidase antibody(TPOAb),25-hydroxyvitamin D[25(OH)D],IL-17 and IL-35 were detected in all subjects.Pearson correlation analysis was used to evaluate the correlation between various indicators.Results Serum 25(OH)D and IL-35 levels in HT group were significantly lower than those in the normal control group(P<0.05),while IL-17 level was significantly higher than that in the normal control group(P<0.05).Compared with the normal thyroid function group,the serum 25(OH)D level of the clinical hypothyroidism group was significantly reduced(P<0.05),and the vitamin D deficiency rate of the subclinical hypothyroidism group and clinical hypothyroidism group was increased(P<0.05).There was no significant difference in serum 25(OH)D between subclinical hypothyroidism group and clinical hypothyroidism group(P>0.05).Pearson correlation analysis showed that after adjustment of age,serum 25(OH)D level in the HT group was negatively correlated with TSH,TPOAb,and IL-17(r values were-0.320,-0.254,and-0.339,P<0.05),positively correlated with IL-35(r=0.243,P<0.05),but not related with FT3,FT4,or TgAb(r values were 0.181,0.012,0.018,P>0.05).Conclusion The serum vitamin D level of HT patients is obviously insufficient,which is correlated with IL-17 and IL-35,suggesting that vitamin D level may be related to the onset and severity of HT. |
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| Keywords: | Interleukin 17 Interleukin 35 Vitamin D Hashimoto thyroiditis |
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