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幽门螺杆菌相关检测对消化性溃疡的诊断价值
引用本文:黄平,王健,许玮琦.幽门螺杆菌相关检测对消化性溃疡的诊断价值[J].检验医学,2021(1).
作者姓名:黄平  王健  许玮琦
作者单位:四川省阿坝州林业中心医院医学检验科
摘    要:目的探讨幽门螺杆菌(Hp)检测对消化性溃疡(PU)的诊断价值。方法选取214例PU患者(PU组)、146例慢性浅表性胃炎(CSG)患者(CSG组),以118名健康体检者为对照(对照组)。对所有研究对象进行14C尿素酶呼气试验,并采用免疫印迹法检测其Hp抗体血清分型。结果PU组、CSG组和对照组14C尿素酶呼气试验阳性率分别为85.51%(183/214)、76.03%(111/146)和42.37%(50/118),组间比较差异有统计学意义(P<0.05);PU组、CSG组Ⅰ型Hp感染率高于对照组,PU组Ⅰ型Hp感染率高于CSG组(P<0.05);PU组、CSG组细胞毒素相关蛋白(CagA)+空泡毒素A蛋白(VacA)抗体阳性率均明显高于对照组,PU组CagA+VacA抗体阳性率高于CSG组(P<0.05);PU组、CSG组CagA+VacA抗体阳性率均高于单一CagA/VacA抗体阳性率。结论Hp抗体血清分型检测可为PU的临床诊断提供可靠的实验室依据,具有重要的临床价值。

关 键 词:幽门螺杆菌  消化性溃疡  抗体  诊断

Diagnostic role of Helicobacter pylori detection in patients with peptic ulcer
HUANG Ping,WANG Jian,XU Weiqi.Diagnostic role of Helicobacter pylori detection in patients with peptic ulcer[J].Laboratory Medicine,2021(1).
Authors:HUANG Ping  WANG Jian  XU Weiqi
Institution:(Department of Clinical Laboratory,Aba Forestry Central Hospital,Chengdu 611830,Sichuan,China)
Abstract:Objective To investigate the diagnostic role of Helicobacter pylori(Hp)detection in patients with peptic ulcer(PU).Methods A total of 214 patients with PU(PU group),146 patients with chronic superficial gastritis(CSG group),and 118 healthy subjects(control group)were enrolled in this study.All the subjects received 14C urease breath test,and Hp antibody typing of the 3 groups were detected by immunoblotting.Results The positive rateof 14C urease breath test of PU,CSG and control groups was 85.51%(183/214),76.03%(111/146)and 42.37%(50/118),respectively,and there were significant differences between groups(P<0.05).The Hp typeⅠinfectious rate of PU and CSG groups was higher than that of control group,and the Hp typeⅠinfectious rate of PU group was higher than that of CSG group(P<0.05).The cytotoxin-associated protein(CagA)+vacuolar protein toxin A(VacA)antibody positive rate of PU group and CSG group was higher than that of control group,and CagA+VacAantibody positive rateof PU group was higher than that of CSG group(P<0.05).CagA+VacA antibody positive ratewas higher than single CagA or VacA antibody positive ratein both PU group and CSG group.Conclusion Hp antibody serotyping assay can provide a reliable reference for clinical diagnosis of PU and hasimportant clinical value.
Keywords:Helicobacter pylori  Peptic ulcer  Antibody  Diagnosis
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