孤立性肺结节危险因素分析

目的 分析孤立性肺结节(SPN)的危险因素.方法 选取在扬州大学附属医院胸外科行手术治疗且已确定病理类型的127例SPN患者为研究对象,剔除纯磨玻璃结节(pGGO)患者后共纳入80例患者.回顾性分析纳入患者的性别、年龄、吸烟史、既往恶性肿瘤史、血清癌胚抗原(CEA)、血清可溶性细胞角蛋白19片段(CYFRA21-1)以...

Analysis in risk factors of solitary pulmonary nodules

Objective To analyze the risk factors of solitary pulmonary nodules(SPN).Methods A total of 127 patients with SPN who had determined the pathologic types and underwent thoracic surgeries in Yangzhou University Affiliated Hospital were collected as study objects,and a total of 80 patients were included after exclusion of those with pure ground-grass opacity(pGGO).The clinical data such as gender,age,smoking history,past cancer history,carcinoembryonic antigen(CEA),cytokeratin 19 fragment(CYFRA21-1),nodule diameter,location,burr sign,lobulation,pleural indentation sign,vascular convergence sign,calcification and vacuole sign were retrospectively analyzed.Taking pathological examination results as gold standard,these patients were divided into benign group and malignant group.Univariate analysis was used to explore the influencing factors of SPN,and Logistic multivariate analysis was used to determine its independent risk factors.Results There were significant differences in age,past cancer history,CEA and CYFRA21-1 levels,nodule diameter,burr sign,lobulation between the two groups univariate analysis(P<0.05).Logistic regression analysis showed that past cancer history,CEA as well as CYFRA21-1 levels,and lobulation were independent risk factors for malignat SPN.The sensitivity and specificity of predictive model for benign or malignant SPN were 70.90%and 92.00%,respectively.Conclusion Past cancer history,CEA as well as CYFRA21-1 levels and lobulation are independent risk factors for malignat SPN and the prediction model has a certain clinical value.