NLR、PCT、CRP联合检测对早期COVID-19的诊断价值

目的 探讨中性粒细胞/淋巴细胞比值(NLR)、降钙素原(PCT)和C反应蛋白(CRP)对早期新型冠状病毒肺炎(COVID-19)的诊断价值.方法 选取咸宁市第一人民医院230例疑似COVID-19患者,根据胸部电子计算机断层扫描(CT)、严重急性呼吸综合征冠状病毒2(SARS-CoV-2)核酸、病毒血清学抗体和血培养检...

Early diagnosis value of NLR,PCT and CRP combined determination for COVID-19

Objective To investigate the value of neutrophil/lymphocyte ratio(NLR),procalcitonin(PCT)and C-reactive protein(CRP)determinations in the early diagnosis of corona virus disease 2019(COVID-19).Methods A total of 230 suspected COVID-19 patients were enrolled and classified into COVID-19 group(80 cases),cold group(100 cases)and bacterial group(50 cases)according to thorax computed tomography(CT),severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)nucleic acid,viral serological antibody and blood culture results.The levels of white blood cell(WBC)count,the absolute value of neutrophil(NEUT#),the absolute value of lymphocyte(LYMPH#),the percentage of lymphocyte(LYMPH%),the absolute value of easinosphils(EO#),NLR,PCT and CRP among the 3 groups were compared.Results Compared with cold group,COVID-19 group had higher levels of NLR and CRP,and the levels of LYMPH%,LYMPH#and EO#were lower(P<0.05).Compared with bacterial group,COVID-19 group had lower levels of LYMPH#,EO#,NEUT#,PCT and WBC count(P<0.05).Compared with cold group,COVID-19 group had higher proportions of WBC count<4.00,LYMPH#<0.80,LYMPH%<20%,EO#<0.05,NLR>3.0 and CRP≥10.00(P<0.05).Compared with bacterial group,COVID-19 group had higher proportions of WBC count<4.00,NEUT#<2.00,LYMPH#<0.80 and EO#<0.05(P<0.05)and lower proportions of WBC count>10.00,NEUT#>7.00,EO#>0.50,PCT≥0.50(P<0.05).Conclusions Decreased LYMPH#,normal PCT and increased NLR and CRP are early markers of COVID-19 patients.The combined determination can be used as a supplement to SARS-CoV-2 nucleic acid determination.