血清内皮细胞特异分子-1、脂肪特异性丝氨酸蛋白酶抑制剂水平对2型糖尿病大血管病变诊断的临床价值

目的 探讨血清内皮细胞特异分子-1(Endocan-1)、脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)水平对2型糖尿病(T2DM)大血管病变(MVC)的临床诊断意义.方法 选取72例患者,根据是否合并大血管疾病,分为T2DM组36例和MVC组36例;此外,选同期36例健康者作为对照组.利用酶联免疫吸附检测技术(ELIS...

Values of serum endothelial cell specific molecule-J and visceral adipose tissue-derived serine protease inhibitor levels in the diagnosis of type 2 diabetic macroangiopathy

Objective To investigate the clinical significance of serum endothelial cell specific molecule-1(Endocan-1)and visceral adipose tissue-derived serine proteaseinhibitor(Vaspin)levels in the diagnosis of type 2 diabetes mellitus(T2DM)macroangiopathy(MVC).Methods Seventy-two patients were selected and divided into T2DM group(n=36)and MVC group(n=36)according to whether they were complicated with macrovascular disease.In addition,36 healthy subjects were selected as control group.The levels of Endocan-1 and Vaspin in serum of the three groups were determined by enzym-linked immunosorbent assay.Results The levels of serum Endocan-1 in T2DM group and MVC group were significantly higher than that in the control group,and the level of serum endocan-1 in MVC group was significantly higher than that in T2DM group(P<0.05).The level of Vaspin in MCV group was significantly lower than that in T2DM group and control group,and the level of Vaspin in T2DM group was significantly higher than that in control group(P<0.05).Endocan-1 was positively correlated with T2DM complicated with macrovascular disease,while Vaspin was negatively correlated with T2DM complicated with macrovascular disease.The areas under curve(AUC)of Endocan-1 and Vaspin in MVC group were 0.910%and 0.720%,and the cut-off values were 1410 pg/mL and 890 pg/mL,respectively.The sensitivity was 81%and 85%,and the specificity was 76%and 73%,respectively.Conclusion Serum Endocan-1 and Vaspin levels are correlated with T2DM macroangiopathy,which can be used as the diagnostic basis for T2DM macroangiopathy.