维甲酸对动脉内皮损伤后血管壁t—PA含量的影响

目的和方法：观察动脉损伤后血管壁中纤溶酶原激活物（ｔ－ＰＡ）浓度的变化以及分化诱导剂维甲酸对其影响。结果：动脉内皮损伤后１周，血管ｔ－ＰＡ浓度达高峰，此后持续下降，但直至术后４周仍高于正常血管。用维甲酸后，尽管术后１、２周血管ｔ－ＰＡ水平仍高于正常，但于第４周恢复正常，而且ｔ－ＰＡ水平各期均低于未用药损伤血管。结论：促进平滑肌细胞的分化能抑制在体平滑肌细胞ｔ－ＰＡ的表达。

Effect of retinoic acid on tissue-type plasminogen activator content in injuried rabbit femoral artery

AIM and METHOD:Changes of tissue-type plasminogen activator(t-PA) content in vessel wall after artery injury and effect of retinoic acid(RA), a differentiation inducing agent, on that were investigated. RESULTS: t-PA concentration increased at all stages after artery injury and reached its maximium at 1 week. Although t-PA levels in RA treated arteries were higher than that of the normal arteries in the first 2 weeks , total t-PA protein was decreased by treatment with RA when compared with the group without RA. CONCLUSION: RA inhibited expression of t-PA by vascular smooth muscle cells in vivo, this may have beneficial effect on intimal thickening after artery injury. .