Use of surface-enhanced Raman scattering as a prognostic indicator of acute kidney transplant rejection |
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| Authors: | Jingmao Chi Thet Zaw Iliana Cardona Mujtaba Hosnain Neha Garg Heather R. Lefkowitz Peter Tolias Henry Du |
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| Affiliation: | 1Department of Chemical Engineering and Materials Science, Stevens Institute of Technology, Hoboken, NJ, 07030, USA;2Newark Beth Israel Medical Center, Newark, NJ, 07112, USA;3Center for Healthcare Innovation, Stevens Institute of Technology, Hoboken, NJ, 07030, USA |
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| Abstract: | We report an early, noninvasive and rapid prognostic method of predicting potential acute kidney dysfunction using surface-enhanced Raman scattering (SERS). Our analysis was performed on urine samples collected prospectively from 58 kidney transplant patients using a He-Ne laser (632.8 nm) as the excitation source. All abnormal kidney function episodes (three acute rejections and two acute kidney failures that were eventually diagnosed independently by clinical biopsy) consistently exhibited unique SERS spectral features in just one day following the transplant surgery. These results suggested that SERS analysis provides an early and more specific indication to kidney function than the clinically used biomarker, serum creatinine (sCr).OCIS codes: (170.5660) Raman spectroscopy, (240.6695) Surface-enhanced Raman scattering, (170.6510) Spectroscopy, tissue diagnostics, (160.4236) Nanomaterials |
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