肺癌患者骨髓微小转移灶的检测及其临床意义

目的：检测肺癌患者骨髓微小转移灶，并探讨其临床意义。方法：用免疫组化法检测肺癌患者骨髓上皮膜抗原（EMA）阳性表达细胞，分析其与肺癌病理类型、分期及远处转移的关系。结果：112例肺癌患者中36例骨髓检出EMA阳性细胞，阳性率为32.1％。EMA阳性细胞的检出率与病期及远处转移有关，晚期及已发生转移的病例检出率明显增高。结论：骨髓EMA表达阳性细胞的检测，可作为评价肺癌患者病期及转移倾向的重要指标之一。

Detection of micrometastasis in the bone marrows in lung cancers

Objectives:To study the relationship among the bone marrow micrometastasis,the clinical stages and the general metastasis in lung cancers. Methods:The bone marrow epithelial membrane antigen (EMA) positive cells from patients with lung cancers were measured by immunocytochemical assay by an antibody probe. Results:EMA positive cells were detected in the bone marrows in 36 patients (32.1%), the positive rates correlated with the stages of patients, and the recurrence rate in patients with remote metastasis were higher than those without bone marrow metastasis. Conclusions: The detection of EMA positive cells is important in evaluating the stage of patients with lung cancers and also to evaluate the possibility of recurrence and genenral metastasis.