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Modulation of prepulse inhibition through both M1 and M4 muscarinic receptors in mice
Authors:Morgane Thomsen  Jürgen Wess  Brian S. Fulton  Anders Fink-Jensen  S. Barak Caine
Affiliation:(1) Alcohol and Drug Abuse Research Center, McLean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA;(2) Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA;(3) Laboratory of Neuropsychiatry, Rigshospitalet University Hospital, 9 Blegdamsvej, 2100 Copenhagen, Denmark;(4) Department of Pharmacology, University of Copenhagen, 9 Blegdamsvej, 2100 Copenhagen, Denmark;(5) Present address: Center for Drug Discovery, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
Abstract:

Rationale  

Muscarinic cholinergic M1 and M4 receptors may participate in schizophrenia’s etiology and have been proposed as targets for antipsychotic medications.
Keywords:
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