Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer |
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| Authors: | Saskia M Wilting Robert AA van Boerdonk Florianne E Henken Chris JLM Meijer Begoňa Diosdado Gerrit A Meijer Carlos le Sage Reuven Agami Peter JF Snijders Renske DM Steenbergen |
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| Affiliation: | 1.Department of Pathology,VU University Medical Center,Amsterdam,The Netherlands;2.Division of Gene Regulation,the Netherlands Cancer Institute,Amsterdam,The Netherlands |
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| Abstract: | Background A substantial number of microRNAs (miRNAs) is subject to epigenetic silencing in cancer. Although epigenetic silencing of tumour suppressor genes is an important feature of cervical cancer, little is known about epigenetic silencing of miRNAs. Since DNA methylation-based silencing of hsa-miR-124 occurs in various human cancers, we studied the frequency and functional effects of hsa-miR-124 methylation in cervical carcinogenesis. |
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