Autoantibodies against platelet-derived growth factor receptor alpha in patients with systemic lupus erythematosus |
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Authors: | Kazuhiro Kurasawa Satoko Arai Takayoshi Owada Reika Maezawa Kotaro Kumano Takeshi Fukuda |
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Institution: | (1) Clinical Immunology, School of Medicine, Dokkyo Medical University, 880 Kita-Kobayashi, Mibu Tochigi, 321-0293, Japan |
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Abstract: | Autoantibody against platelet-derived growth factor receptors (PDGFRs) has been reported in scleroderma (SSc). However, it
remains unknown whether anti-PDGFRs antibody exists in collagen vascular diseases other than SSc. To answer the question,
we developed an ELISA system and examined sera from patients with SLE (n = 75), SSc (n = 31), RA (n = 25) and control individuals. We also reviewed medical records to clarify clinical features of patients with anti-PDGFRα
antibody. To examine the functions of anti-PDGFRα antibody in patients, fibroblasts were cultured and stimulated in the presence
of purified IgG from patients, and their cell numbers were counted. Anti-PDGFRα antibody was detected in 29% of patients with
SLE and in 21% of patients with SSc. Anti-PDGFRα antibody was found in 36% with active SLE, but in 10% in an inactive phase.
Immunosuppressive therapy decreased the titer of the antibody. Patients with anti-PDGFRα antibody frequently developed a rash
and hematological abnormalities, particular hemolytic anemia. Moreover, anti-PDGFRα antibody in SLE failed to demonstrate
agonistic or antagonistic activities on PDGFR signaling. These findings indicate that nonfunctional anti-PDGFRα autoantibody
exists in patients with SLE as well as those with scleroderma, and that the antibody could be a marker of disease activity
and may be a marker of a subgroup of SLE. |
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