| Abstract: | We studied the effects of recombinant granulocytic CSF on heart remodeling in BALB/c mice after cryodestruction. Administration
of granulocytic CSF was started 1 day after cryodestruction (subcutaneously, 10 μg/kg/day, for 4 days). As early as after
the first injection, leukocytosis in the peripheral blood started to develop, leukocyte count peaked on days 4-6 and returned
to normal on day 14. Treatment with granulocytic CSF significantly increased the content of progenitor cells in the bone marrow
and led to rapid development of the inflammatory reaction and myocardium infiltration with mononuclear cells. Injections of
granulocytic CSF did not reduce scar area, but provided significantly less pronounced heart hypertrophy, which attests to
its better functional properties. By day 30 after cryodestruction, control animals and animals receiving granulocytic CSF
exhibited similar morphological picture at the site of damage. Thus, our regimen of granulocytic CSF administration produced
a mobilizing effect on bone marrow progenitor cells and postinfarction heart remodeling. Direct effects of granulocytic CSF
on the heart have to be established for its use in the treatment of myocardial infarction. |
