心血管病传统危险因素与糖尿病及其前期关系

目的探讨传统心血管病危险因素与糖尿病及其前期的关联性,为糖尿病的防治提供参考依据。方法采用随机抽样方法对在浙江省湖州市爱山、龙泉和飞英3个街道共1 197名55～75岁的常住居民进行体格检查和血糖检测,采用Logistic回归分析方法分析传统心血管病危险因素与糖尿病及其前期的关联性。结果 1 197名常住居民中,血糖正常者807名,占67.42%,糖尿病前期者267例,占22.31%,糖尿病者123例,占10.27%;3组人群空腹血糖和餐后2 h血糖值分别为(4.83±0.61)、(5.76±0.61)、(6.99±1.43)mmol/L和(5.46±1.65)、(7.94±2.63)、(13.45±4.01)mmol/L;年龄、体质指数(BMI)、中心性肥胖、腹围、臀围、腰臀比和血压等传统心血管病危险因素在正常血糖组、糖尿病前期组和糖尿病组3组人群中分布不同,差异均有统计学意义(P<0.05);多因素Logistic回归分析结果表明,以正常血糖组为参照组,年龄、BMI、中心性肥胖、腹围、臀围、腰臀比和血压与糖尿病前期存在关联性;以正常血糖组为参照组,年龄、BMI、中心性肥胖、腹围、臀围、腰臀比和血压与糖尿病存在关联性;以糖尿病前期组为参照组,中心性肥胖、腹围和腰臀比与糖尿病存在关联性。结论年龄、BMI、中心性肥胖、腹围、臀围、腰臀比、血压等传统心血管病危险因素与糖尿病及其前期均存在关联性。

Relationships between conventional cardiovascular risk factors and pre-diabetes and diabetes

Objective To explore the associations of conventional cardiovascular risk factors(age,gender,body mass index(BMI),central obesity,waist circumference,hip circumference,abdominal circumference,waist-hip ratio,and blood pressure) with pre-diabetes and diabetes.Methods A total of 1 197 permanent residents aged 55-75 years from communities were investigated.Logistic regression analysis was used to analyze the associations between conventional cardiovascular risk factors,interactions of inflammation and immune-related factors,and other factors and pre-diabetes and diabetes.Results The proportions of overweight and obesity(based on BMI) were 36.1%,51.3%,and 53.7%,respectively,in the normal blood sugar group,pre-diabetes group,and diabetes group;the proportions of central obesity were 47.2%,64.0%,and 75.6% in the three groups;and the proportions of high blood pressure were 36.2%,49.4%,and 53.7%.Multivariate logistic regression analysis results showed that age,BMI,central obesity,abdominal circumference,hip circumference,waist-hip ratio,and blood pressure were related to both pre-diabetes and diabetes(P<0.05 for trend tests);compared with the pre-diabetes group,there were statistically significant correlations between central obesity,abdominal circumference,and waist to hip ratio and diabetes(P<0.05).Conclusion Both pre-diabetes and diabetes are related to multiple conventional cardiovascular risk factors.