新型毒品滥用者大脑神经毒性损害的PET研究

目的:通过认知功能检测结合PET影像学研究新型毒品滥用者大脑神经毒性损害的改变。方法:纳入华西医院精神卫生中心2010年1月-2010年5月新型毒品滥用者共18例,采用临床症状评估、认知功能检测和PET检查结合的方法,研究新型毒品滥用者的神经精神毒性损害的程度和相关脑区的改变。结果:在临床表现症状中,广泛性焦虑所占比例最高,达到72.2%的新型毒品依赖者出现广泛性焦虑症状。吸食新型毒品种类以冰毒为主,(在认知功能测验中,单字、单色、双色患者组均较对照组长,颜色字意的干扰、颜色记忆与对照组相比存在的差异具有统计学意义(P<0.05)。PET的结果显示,糖代谢降低的区域主要集中在额叶组织,其余各个大脑区域(顶叶,颞叶,海马,大小脑等组织)均有不同比例的糖代谢降低。PET显示脑区(纹状体、海马、额叶)出现代谢性变化与认知功能(记忆、焦虑、注意力)损害相对应具有相关性,具有统计学意义(P<0.05)。结论:新型毒品滥用者的PET显像各脑区均出现了有临床意义的改变,与认知损害结果一致,具有重要意义。

A STUDY ON THE BRAIN NEUROTOXICITY OF THE SYNTHETIC DRUGS BY PET

Objective:To investigate the brain neurotoxicity of synthetic drugs by cognitive function testing and PET imaging.Methods:From January to May in 2010,the clinical symptoms,cognitive function testing and PET in 18 people were analyzed to investigate the brain neurotoxicity of synthetic drugs.Results:In the clinical symptoms,72.2% subjects had the generalized anxiety symptoms.The main abused drug was methamphetamine.There were significant differences in cognitive functions in the quiz,vocabulary,monochromator,double color,the interference of the color words meaning,the color memories,which were compared with the control group(P<0.05).It showed glucose metabolism decreased in the frontal lobe area in PET,which are mainly concentrated tissue,the rest in various brain regions(parietal lobe,temporal lobe,hippocampus,brain size,and other organizations),which have reduced glucose metabolism different ratios,indicating that there was damage to the brain.Conclusion:It was important that the clinical changes were found in the PET imaging as well as the cognitive damage in abusers who were addicted synthetic drugs.