| 烧伤休克延迟补液后氧自由基对心肌的损伤 |
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| 引用本文： | 路卫,陈玉林,刘林,孟凡寅,葛绳德,方之扬.烧伤休克延迟补液后氧自由基对心肌的损伤[J].中华整形外科杂志,1995(2). |
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| 作者姓名： | 路卫 陈玉林 刘林 孟凡寅 葛绳德 方之扬 |
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| 作者单位： | 长海医院烧伤研究所，徐州市第三医院烧伤科 |
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| 摘 要： | 采用大鼠２５％ＴＢＳＡＩＩＩ度烧伤模型，动态观察了大鼠心肌在不补液，立即补液，延迟补液三种复苏条件下的超氧阴离子Ｏ２－、丙二醛（ＭＤＡ）含量、乳酸脱氢酶同工酶（ＬＤＨ１）和肌酸磷酸激酶（ＣＰＫ－ＭＢ）的活力，结果表明烧伤早期心肌中，可产生多量的Ｏ２－，并可发生脂质过氧化反应，尤其在延迟补液组，不但ＭＤＡ含量增加，且ＬＤＨ１和ＣＰＫ－ＭＢ活力也明显增加。提示烧伤后立即补液对心肌仅有一定保护作用，故严重烧伤后的液体复苏中应辅以新的内容。
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| 关 键 词： | 烧伤，液体复苏，心肌，氧自由基 |
The injury of heart of rats sustaining delayed fluid resuscitation after burn shock |
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| Lu Wei,Chen Yulin,Liu Lin,et al..The injury of heart of rats sustaining delayed fluid resuscitation after burn shock[J].Chinese Journal of Plastic Surgery,1995(2). |
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| Authors: | Lu Wei Chen Yulin Liu Lin |
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| Abstract: | Delayed fluid resuscitation of burn shock may lead to many harmful effects.We investigated the injury of heart of burned rats having no fluid resuscitation,immediate and delayed fluid replacement.We used electron spin resonance(ESR)to determine the presence of oxygen free radicals(OFR).We also found significant increase in malondialdehyde(MDA)in delayed resuscitation group.The activity of lactate dehydrogenase isoenzyme(LDH)and creatine phosphokinase isoenzyme(CPK-MB)were increased in the latter group.Immediate fluid replacement can not protect the heart perfectly.Some new measure should be added to the fluid replacement in burn shock. |
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| Keywords: | Burn shock Fluid resuscitation Oxygen free radicals Heart |
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