稳定性心绞痛患者PCI围手术期血浆超敏C反应蛋白与血管再狭窄

目的：探讨超敏C反应蛋白（hs-CRP）在稳定性心绞痛患者PCI围手术期中的变化与术后再狭窄的关系。方法：分析78例稳定性心绞痛患者临床资料,分析其在PCI术前、术后即刻、术后24 h、术后72 h及复查冠脉造影前的超敏hs-CRP水平;术后6个月行冠脉造影复查后分为再狭窄组（10例）及无再狭窄组（68例）;比较两组hs-CRP水平。结果：再狭窄组与无再狭窄组比较,两组各项临床特征差异无统计学意义;PCI术后所有患者的hsCRP水平与术前相比均有明显升高,而且再狭窄组患者术后72 h hs-CRP水平高于无再狭窄组（9.81±4.76 vs6.64±2.89,P〈0.01）,术后24 h时再狭窄组hs-CRP水平高于无再狭窄组（3.77±1.52 vs 2.43±1.05,P〈0.05）。结论：稳定性心绞痛患者PCI术后24 h、72 h时hs-CRP明显增高时,提示患者可能出现支架内再狭窄。

The Relationship Between hs-CRP and Restenosis in Stable Angina Patients During PCI

Objective:To evaluate the relationgship between hs-CRP and restenosis in stable coronary artery disease patients during PCI.Methods:clinical data of 78 stable angina patients were retrospectively analyzed.The levels of hs-CRP pre-PCI,pos-PCI,24-hours-after PCI(24h-PCI) and 72-hours-after PCI(72h-PCI) were respectively measured. Their coronary angiographies were executed again 6-months after PCI.According to the results,those patients were divided into restenosis group(10 cases) and controlled group(68 cases).Results:There was no significant difference in the clinical features between the two groups;In all the patients after PCI,the level of hs-CRP was significantly higher than that before PCI.In the restenosis group,the level of hs-CRP 72h -PCI was higher than that in the controlled group(9.81±4.76 vs 6.64±2.89,P<0.01) and the level of hs-CRP 24h-PCI was higher in the restenosis group than that in the controlled group(3.77±1.52 vs 2.43±1.05,P<0.05).Conclusion:In the patients with stable angina,the increasing level of hs-CRP after PCI indicated the possible appearance of restenosis after PCI.