还原型谷胱甘肽对异甘草酸镁治疗酒精性肝炎疗效的影响

 目的 探究还原型谷胱甘肽对异甘草酸镁治疗酒精性肝炎疗效的影响。方法 选择2014年1－12月酒精性肝炎患者140例，按随机数字表法分为实验组和对照组，每组70例。对照组给予异甘草酸镁注射液治疗，实验组在对照组治疗基础上加用还原型谷胱甘肽注射液。以4周为一疗程，观察并记录两组患者肝功能指标丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)、总胆红素(TBIL)。结果 治疗后实验组肝功能指标ALT、AST、GGT、总胆红素水平优于对照组，具有统计学意义(P<0.05)。实验组有效率(94.29%)高于对照组(81.43%)，差异有统计学意义(P<0.05)。治疗后实验组无不良反应发生;对照组不良反应发生率为10%，高于实验组(P<0.05)。结论 还原型谷胱甘肽可以提高异甘草酸镁治疗酒精性肝炎的效果。

Effects of magnesium isoglycyrrhizinate combined with reduced glutathione on the liver function indexes and the clinical efficacy for the alcoholic hepatitis

Objective To study the effects of magnesium isoglycyrrhizinate combined with reduced glutathione on the liver function indexes and the clinical efficacy for the alcoholic hepatitis.Methods 140 patients with alcoholic hepatitis treated in this hospital from January 2014 to December 2014 were randomly divided into the study group and the control group, 70 patients in each group. Both groups were given conventional therapy. And in addition, the control group was given intravenous dripping injection of magnesium isoglycyrrhizinate alone, and the study group was given reduced glutathione combined with intravenous dripping injection of magnesium isoglycyrrhizinate. Both groups were given one treatment course (4 weeks). The liver function indexes including ALT, AST, GGT and TBIL, and the clinical effect of the treatment were observed and compared.Results After the treatment, the level of the liver function indexes ALT, AST, GGT and TBIL in the study group were significantly better than in the control group(P<0.05). And the effective rate in the study group was 94.29%, obviously higher than the effective rate 81.43% in the control group. There was significant difference between the two groups(P<0.05). After the treatment, there was no adverse reaction in the study group. And the incidence of the adverse reaction in the control group was 10%, obviously higher than that in the study group(P<0.05).Conclusions Magnesium isoglycyrrhizinate combined with reduced glutathione is effective for alcoholic hepatitis, and it is worthy of clinical application and promotion.