二甲双胍与艾塞那肽治疗新诊断2型糖尿病的疗效及其对血糖波动的影响

 目的 比较艾塞那肽与二甲双胍治疗新诊断2型糖尿病的疗效及其对血糖波动的影响。方法 将68例新诊断2型糖尿病患者随机分为2组,分别为二甲双胍组35例,艾塞那肽组33例。治疗12周,比较2组治疗前后空腹血糖(FBG),餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、血脂、体重指数,以及血糖波动指标日内平均血糖波动幅度(MAGE)、最大血糖波动幅度(LAGE)、平均餐后血糖波动幅度(MPPGE)的变化。结果 治疗12 周后,两组FBG、2 h PG、HbA1c、血糖波动指标较治疗前均明显下降,两组治疗后无统计学差异;两组治疗后三酰甘油(TG)较治疗前明显降低(P<0.05),二甲双胍组(1.88±0.57)mmol/L,艾塞那肽组(1.58±0.21)mmol/L,相比二甲双胍组,艾塞那肽组下降更为明显(P<0.05);体重指数艾塞那肽组治疗前体重(25.14±2.21)kg/m²,治疗后(23.16±1.46)kg/m²,治疗前后比较具有统计学差异(P<0.05)。结论 艾塞那肽与二甲双胍对新诊断2型糖尿病控制血糖效果具有同等的疗效,艾塞那肽在降低三酰甘油及体重方面更为显著。

Efficacy of metformin and exenatide in newly diagnosed type 2 diabetes and their effect on glucose fluctuation

Objective To study the effect of exenatide and metformin on treatment of newly diagnosed type 2 diabetes.Methods 68 patients with newly diagnosed type 2 diabetes were randomly divided into two groups: metformin group (35 patients) and exenatide group (33 patients) and were treated for 12 weeks. The changes in FBG, 2 h PG, HbA₁c, CHO, TG, LDL, BMI, MAGE, LAGE and MPPGE were observed in two groups.Results After 12 weeks of treatment, in two groups the levels of FBG, 2 h PG, HbA₁c, MAGE, LAGE and MPPGE showed significant decrease (P<0.05), and no significant difference was observed. After treatment,TG was significantly lower than before treatment in the two groups (P<0.05), TG was (1.88±0.57) mmol/L in metformin group and (1.58±0.21) mmol/L in exenatide group; compared with metformin group, in the exenatide group it decreased more significantly (P<0.05). In exenatide group, body mass index (BMI) was (25.14±2.21) kg/m² before treatment and (23.16±1.46) kg/m² after treatment, BMI was significantly decreased after treatment (P<0.05).Conclusions In patients with newly diagnosed type 2 diabetes, exenatide and metformin can remarkably control blood glucose. The effect of exenatide on body weight and TG are better than that of metformin.