2型糖尿病伴血脂异常患者外周血白细胞及淋巴细胞的变化与临床意义

 目的 探讨2型糖尿病伴血脂异常患者白细胞、淋巴细胞及淋白细胞比率的变化与临床意义。方法 分别收集2型糖尿病血脂异常225例患者及血脂正常109例的静脉血进行全血细胞分析。结果 (1)白细胞数在2型糖尿病患者血脂异常组[(6.50±1.60) ×10⁹/L]及血脂正常组[(6.30±1.63)×10⁹/L]差异无统计学意义;(2)淋巴细胞数在2型糖尿病血脂异常组[(2.08±0.74)×10⁹/L]高于血脂正常组[(1.89±0.60)×10⁹/L，P=0.012];(3)淋白细胞比率在2型糖尿病血脂异常组(0.32±0.091)高于血脂正常组(0.31±0.089，P=0.016)。结论 2型糖尿病患者血脂异常伴有淋巴细胞数量改变，可能与血脂异常参与某些炎性反应有关。

Changes and clinical significance of leukocytes and lymphocytes in patients with type 2 diabetes and dyslipidemia

Objective To investigate the change of leukocytes, lymphocytes and ratio of lymphocytes and the clinical significance in type 2 diabetic patients with dyslipidemia. Methods We collected venous blood from 225 type 2 diabetes patients with dyslipidemia and 109 type 2 diabetes patients with normal lipid,then analyzed difference in blood routine between the two groups. Results (1)The leukocyte count in type 2 diabetes patients with dyslipidemia was[(6.50±1.60)×10⁹/L] and in type 2 diabetes with normal lipid was[(6.30±1.63) ×10⁹/L],the without P value is 0.326( greater than 0.05).statically significant difference.(2)The number of lymphocytes in type 2 diabetes patients with dyslipidemia was[(2.08±0.74)×10⁹/L] and in type 2 diabetes patients with normal lipid was[(1.89±0.60)×10⁹/L,P=0.012],the P value is 0.012 (less than 0.05).(3)The leukocyte tlymphocyte ratio in type 2 diabetes patients with dyslipidemia was(0.32±0.091) and in type 2 diabetes psstients with normal lipid was(0.31±0.089).the P value is0.016 ( less than 0.05).In the two groups,the lymphocyte cell count and leukocyted lymphocyte ratio has statically significant difference Conclusions In patients with type 2 diabetes ,dyslipidemia causes change in the number of lymphocytes and may beengaged in certain inflammatory reaction.