纳络酮治疗新生儿缺氧缺血性脑病的疗效分析

目的：观察纳络酮对新生儿缺氧缺血性脑病的临床疗效。方法：对32例缺氧缺血性脑病的患儿使用纳络酮治疗，均给予静脉用药，第1天0．4mg加入10％葡萄糖30ml，中静滴，第2，3天给0．8mg加入10％葡萄糖50ml中静滴，每次在4h左右滴完，连续3d，结果：32例缺氧缺血性脑病中，重度17例，存活11例，死亡6例，留后遗症4例，中度8例，存活7例，死亡1例，留后遗症1例；轻度7例，均存活，无后遗症发生。结论：新生儿缺氧缺血性脑病使用纳络酮能提高成活率，减少后遗症的发生。

Analysis of the effect of naloxone on neonatal hypoxia-ischemic encephalopathy

Objective To observe the effect of naloxone on HIE.Methods Thirty two cases of HIE received naloxone dissolved in 30ml 10%GS for 3 days intravenously.The dosage of naloxone was 0.4mg in the first day,and 0.8mg in the second and third day,respectively.The time of administration was about 4 hours.Results Of 17 cases of severe HIE,11 cases survived but 4 cases with sequelae,and 6 cases died.Of 8 cases of moderate HIE,7 cases survived but 1 case with sequelae,and 1 case died.All 7 mild cases survived without sequelae.Conclusion Naloxone can increase the survival rate of HIE and decrease the sequelae.