|
|||||
|
|
| RECK、MMP-2在牙周炎患者牙龈组织中的表达 | |
| 引用本文： | 袁健,初秀红,陈卓,陈晖,席清平,周娜,陶学金.RECK、MMP-2在牙周炎患者牙龈组织中的表达[J].临床口腔医学杂志,2012,28(3):149-151. |
| 作者姓名： | 袁健 初秀红 陈卓 陈晖 席清平 周娜 陶学金 |
| 作者单位： | 1. 浙江大学医学院附属口腔医院牙体牙髓科,浙江杭州,310006 2. 烟台经济技术开发区医院,山东 烟台,264006 3. 华中科技大学同济医学院附属同济医院口腔医学中心,湖北武汉,430030 |
| 基金项目： | 浙江省教育厅科研项目资助（Y200909390） |
| 摘 要： | 目的:研究RECK蛋白和MMP-2在牙周炎中的表达及其相互关系。方法:应用免疫组化SP法检测56例牙周炎患者牙周组织和16例正常牙龈组织中RECK和MMP-2的表达。结果:RECK在16例正常牙龈组织中的阳性表达率100%,而在牙周炎牙龈组织中的阳性表达率为51.8%。MMP-2在正常牙龈组织中的阳性表达率为31.3%,而在牙周炎牙龈组织中的阳性表达率为76.8%。牙周炎中RECK与MMP-2的表达呈负相关(P<0.01,r=-0.300)。结论:RECK可能通过调控MMP-2来影响牙周炎的发生与发展。 |
| 关 键 词： | RECK基因 基质金属蛋白酶2 牙周炎 |
Expression of Reversion-inducing-cysteine-rich protein with kazal Motifs and Matrix Metalloproteinase-2 in the periodontitis |
|
| YUAN Jian , CHU Xiu-hong , CHEN Zhuo , CHEN Hui , XI Qing-ping , ZHOU Na , TAO Xue-jin.Expression of Reversion-inducing-cysteine-rich protein with kazal Motifs and Matrix Metalloproteinase-2 in the periodontitis[J].Journal of Clinical Stomatology,2012,28(3):149-151. | |
| Authors: | YUAN Jian CHU Xiu-hong CHEN Zhuo CHEN Hui XI Qing-ping ZHOU Na TAO Xue-jin |
| Institution: | Y UA N Jian, CHU Xiu-hong, CHEN Zhuo, CHEN Hui, Xl Qing-ping, ZH OU Na, TA O Xue -jin.1.Stomatalogy Hospital, Zhejiang University College of Medicine, Zhejiang Hangzhou 310006, China： 2.Hospital of Yantai Economic and Technological Development Zone, Shandong Yantai 264006, China： 3.Center of Stomatalogy, Tonal Hospital Tongji Medical College Huazhong University of Science and Technology,Hubei Wuhan 430030, China. |
| Abstract: | Objective：To study the expression of RECK （reversion-inducing-cysteine-rich protein with kazal mo- tifs） and MMP-2 （matrix metalloproteinase-2） in the periodontitis, and to investigate their roles and correlation in the car- cinogenesis and development in the periodontitis. Method： The immunohistochenfistry SP method was used to study the ex- pression of RECK and MMP-2 in 56 samples of inflamed periodontal tissues from adult periodontitis patients and 16 sam- ples of periodontal healthy controls. Result：The positive expression rate of RECK in the periodontitis was 51.8 %,which was lower than the rate in normal oral mucosa. While the expression rate of MMP-2 were high （76.8 %） in the periodonti- tis. The expression of RECK was negatively correlated with the expression of MMP-2 （P 〈0.01, r=-0.300）. Conclusion： RECK may play an important role in suppressing the occurrence and development of periodontitis through regulating MMP- 2. |
| Keywords: | RECK MMP-2： periodontitis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |