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| 酪氨酸激酶B与VEGF在涎腺腺样囊性癌中的表达及其与侵袭转移相关性的分析 | |
| 引用本文： | 夏勇,农晓琳,杨亦萍,卿海云,李佳荃,黎燕宁,曹阳,李昊,陈琦.酪氨酸激酶B与VEGF在涎腺腺样囊性癌中的表达及其与侵袭转移相关性的分析[J].临床口腔医学杂志,2012,28(2):67-70. |
| 作者姓名： | 夏勇 农晓琳 杨亦萍 卿海云 李佳荃 黎燕宁 曹阳 李昊 陈琦 |
| 作者单位： | 1. 安徽省晥南医学附属(戈)矶山医院口腔医学中心 2. 广西医科大学口腔医院口腔颌面外科,广西南宁,530021 3. 广西医科大学口腔医院口腔病理科,广西南宁,530021 4. 广西医科大学医学实验中心,广西南宁,530021 5. 广西医科大学医学公共卫生学院流行病及统计学教研室 广西南宁 530021 |
| 基金项目： | 国家自然科学基金资助项目（30060082）; 教育部春晖计划启动基金资助项目[教外司留（2003）593号]; 广西卫生厅医药卫生重点资助项目（重200006和重200927）; 广西教育厅资助项目（97095）; 广西自然科学基金重点资助项目（2010GXNSFD013047） |
| 摘 要： | 目的:通过检测酪氨酸激酶B(TrkB)及血管内皮生长因子(VEGF)在涎腺腺样囊性癌(SACC)的表达情况,探讨TrkB和VEGF在SACC侵袭转移中的作用及两者相关关系。方法:采用免疫组织化学S-P法检测47例SACC患者组织病理切片中TrkB和VEGF的表达情况,结合临床资料统计分析,评价TrkB,VEGF在SACC侵袭转移中的作用及两者的相关性。结果:TrkB,VEGF在SACC组织中的阳性率分别是89.36%(42/47例)和85.1%(40/47例),在有神经侵袭、转移及实性型SACC患者组织切片中TrkB和VEGF的表达率均高于无神经侵袭、转移及腺样管状型者,且差别有统计学意义(P<0.05);TrkB和VEGF的表达率成正相关关系(P<0.01)。结论:TrkB,VEGF的表达强弱与SACC的嗜神经侵袭,血行转移能力成正相关关系,表明两者在SACC的侵袭转移过程中具有重要的作用,且TrkB和VEGF的表达呈正相关关系,并由此推测TrkB可以作为抗血管治疗SACC的潜在的靶向目标。 |
| 关 键 词： | 神经生长因子受体 血管内皮生长因子受体 涎腺 腺样囊性癌 嗜神经侵袭 转移 |
An analysis of metastasis and perineural invasion correlated with the expressions of TrKB and VEGF in salivary gland adenoid cystic carcinoma. |
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| XIA Yong , NONG Xiao-lin , YANG Yi-ping , QING Hai-yun , LI Jia-quan , LI Yan-ning , CAO Yang , LI Hao , CHEN Qi.An analysis of metastasis and perineural invasion correlated with the expressions of TrKB and VEGF in salivary gland adenoid cystic carcinoma.[J].Journal of Clinical Stomatology,2012,28(2):67-70. | |
| Authors: | XIA Yong NONG Xiao-lin YANG Yi-ping QING Hai-yun LI Jia-quan LI Yan-ning CAO Yang LI Hao CHEN Qi |
| Institution: | 1.1.Department.of Oral and Maxillofacial Surgery,Stomatological College,Guangxi Medical University,Nanning 530021,China;2.Department.of Oral Pathology,Stomatological College,Guangxi Medical University,Guangxi Nanning 530021,China;3.Medical Research Center,Guangxi Medical University,Guangxi Nanning 530021,China;4.Department.of Epidemiology and Health Statistics,School of Public Health,Guangxi Medical University,Guangxi Nanning 530021,China. |
| Abstract: | Objective:To determine the effect of tyrosine kinase B(TrkB) and vascular endothelial growth factor(VEGF) in the invasion and metastasis of SACC(salivary gland adenoid cystic carcinoma).Investigate the correlation between both of them.Method:The expression of TrkB and VEGF were detected by immunohistochemical staining in 47 cases of ACC of salivary glands.Clinical data were reviewed by multivariate prognostic analysis.Result:The positive rate of TrkB and VEGF in SACC was 89.36 %(42/47) and 85.1 %(40/47) respectively.Express of TrkB and VEGF in perineural invasion,recurrence and solid-type group were higher than non-perineural invasion,non-recurrence and tubular type group.Significant relationship was found in TrkB and VEGF expression,P <0.05.Positive correlation between expression of TrkB and VEGF(P <0.01).Conclusion:The clinic pathological and Kaplan-Meier Survival analysis of this group indicate that TrkB and VEGF play important roles in the invasion and metastasis of SACC.It is possible that TrkB may represent a potential target for antiangiogenic therapy in SACC. |
| Keywords: | TrkB VEGF Salivary gland Adenoid cystic carcinoma Perineural invasion Metastasis |
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