IP-10和IL-6在口腔扁平苔藓中表达的研究

目的:检测正常口腔黏膜与口腔扁平苔藓(OLP)黏膜的上皮和固有层结缔组织中干扰素诱导蛋白10(IP-10)、细胞因子白细胞介素-6(IL-6)mRNA的表达,探讨其在OLP中的作用。方法:应用荧光实时定量RT-PCR技术检测10例OLP黏膜和6例正常口腔黏膜的上皮和固有层结缔组织中IP-10、IL-6mRNA的表达量。结果:OLP黏膜上皮和固有层结缔组织中IP-10、IL-6mRNA的表达均较正常口腔黏膜明显升高(P<0.05),但IP-10、IL-6mRNA的表达量没有明显差异(P>0.05)。结论:OLP组织中趋化因子IP-10、细胞因子IL-6表达量改变可能与其发生发展有一定关系。

The study on the role of interferon-inducible protein 10 and Interleukin-6 in oral lichen planus.

Objective:To detect the expression levels of chemokine IP-10mRNA and cytokine IL-6mRNA in normal oral mucosa and oral lichen mucosal epithelium and lamina propria and to investigate the role of IP-10 and IL-6 on oral lichen planus.Method:The epithelium and lamina propria from 10 cases of oral lichen planus and 6 cases of normal oral mucosa were adopted.Real-time RT-PCR was used to detect the expression levels of IP-10 and IL-6 mRNA.Result:The expression levels of IP-10 and IL-6 mRNA in both epithelium and lamina propria of OLP group are significantly higher than that in normal oral mucosa group(P <0.05).However,the expression levels of IP-10 and IL-6 mRNA showed no significant difference between lamina propria and epithelium(P >0.05).Conclusion:The increase of IP-10 and IL-6 may have some correlation with the pathogenesis and progress of oral lichen planus.