口腔鳞状细胞癌及白斑人乳头瘤病毒16型感染的临床研究

目的:探讨口腔鳞状细胞癌(OSCC)和白斑(LK)患者人乳头瘤病毒16型(HPV-16)感染和临床病理参数之间的相关性。方法:收集30例OSCC和5例LK患者的组织切片,所有病例均经病理学确诊,提取组织DNA,通过巢式PCR检测HPV-16感染情况。结果:HPV-16与TNM分级之间未见相关性,60岁以下女性患者的HPV-16感染率高于60岁以上女性患者(P=0.024),而男性患者未见HPV-16感染和年龄存在相关性(P=0.649)。结论:60岁以下女性OSCC及LK患者中出现较高的HPV-16感染率,提示这可能是新的致癌危险因子。

Human papillomavirus type 16 infection in patients with oral squamous cell carcinomas and leukoplakia

Objective：To evaluate the association of human papillomavirus type 16（HPV type 16） infection and clinicopathological parameters in patients with oral squamous cell carcinomas（OSCC） and oral leukoplakia,Materials and.Method：30 cases of OSCC and 5 cases of oral leukoplakia for HPV type 16 DNA were examined by nest-PCR.Result：No significant correlation was found between HPV type 16 infections and TNM staging.The positive rate of HPV type 16 DNA in young female OSCC patients was significantly higher than that in older female OSCC patients（P =0.024）,but no significant difference was found in the male patitents among age subgroups（P =0.649）.Conclusion：These results suggest that the increased HPV type 16 infections in younger females may attribute to the OSCC tumorigenesis.