血清高敏C反应蛋白和白细胞介素-6水平对冠心病病情评估的价值

目的探讨检测血清高敏C反应蛋白（high sensitivity C-reactive protein,hs-CRP）和白细胞介素-6（interleukin-6,IL-6）对冠心病患者的临床意义。方法检测83例接受经皮冠状动脉介入术治疗的冠心病患者介入治疗前及治疗3个月后血清hs-CRP及IL-6水平,其中急性心肌梗死组16例,不稳定心绞痛组38例,稳定性心绞痛组29例,并与41例健康体检者（对照组）进行比较。结果治疗前急性心肌梗死组和不稳定心绞痛组血清hs-CRP和IL-6水平明显高于对照组（P〈0.01）;稳定性心绞痛组血清hs-CRP水平高于对照组（P〈0.01）;治疗3个月后冠心病3组血清hs-CRP和IL-6水平明显下降,与对照组比较差异无统计学意义（P〉0.05）。结论血清hs-CRP和IL-6水平对冠心病患者治疗及预后有一定价值。

Value of serum high sensitivity C-reactive protein and interleukin-6 levels to evaluating coronary heart disease

Objective To study the clinical significance of detecting serum high sensitivity C-reactive protein and interleukin-6 levels in patients with coronary heart disease.Methods The levels of high sensitivity C-reactive protein and interleukin-6 were detected in 83 patients with coronary heart disease before and three months after percutaneous coronary intervention,in which there were 16 cases of acute myocardial infarction（AMI group）,38 cases of unstable angina pectoris（UAP group）,29 cases of stable angina pectoris（SAP group） and another 41 healthy people were as controls（control group）.Results The interleukin-6 and high sensitivity C-reactive protein levels were significantly higher in AMI and UAP groups than those in control group（P0.01）.The high sensitivity C-reactive protein level was significantly higher in SAP group than that in control group（P0.01）.After three months＇ treatment,the levels of high sensitivity C-reactive protein and interleukin-6 were obviously lower in 83 patients,which showed no significant differences compared with those in control group（P0.05）.Conclusion The serum levels of high sensitivity C-reactive protein and interleukin-6 have some clinical significance in treating and assessing prognosis of patients with coronary heart disease.