| 乙肝病毒Pre S1与HBV M和HBV DNA检测的相关性分析 |
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| 引用本文： | 崔杰峰,潘柏申,贾哲甫,宋斌斌.乙肝病毒Pre S1与HBV M和HBV DNA检测的相关性分析[J].中国实验诊断学,2002,6(3):140-142. |
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| 作者姓名： | 崔杰峰 潘柏申 贾哲甫 宋斌斌 |
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| 作者单位： | 复旦大学附属中山医院检验科,上海,200032 |
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| 摘 要： | 目的 了解PreS1与HBVM和HBVDNA检测的关系及其临床应用价值。方法 PreS1检测采用ELISA方法 ,HBVM检测采用电化学免疫发光法 ,HBVDNA检测采用荧光定量PCR法。结果 PreS1在HBeAg(+)组的检出率86 9% ,明显高于其他HBVM模式组 (P <0 0 1) ;PreS1检出乙肝病毒的灵敏性高于HBeAg检测 ,检测灵敏度为 80 9%(HBeAg为 6 1 8% ) ,检测有效率为 86 1% (HBeAg为 75 7% )。结论 PreS1与HBeAg具有较好的相关性 ,其检测灵敏性 (与HBVDNA的相关性 )和检测有效率都优于HBeAg检测 ,具有较好的临床应用价值。
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| 关 键 词： | 前S1抗原 HBV M HBV DNA |
| 文章编号： | 1007-4287(2002)03-0140-03 |
| 修稿时间： | 2001年8月16日 |
Study of relativity between HBV M and HBV DNA with Pre S1 |
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| CUI Jie-feng,PAN Bai-shen,JIA Zhe-fu,et al..Study of relativity between HBV M and HBV DNA with Pre S1[J].Chinese Journal of Laboratory Diagnosis,2002,6(3):140-142. |
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| Authors: | CUI Jie-feng PAN Bai-shen JIA Zhe-fu |
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| Abstract: | Objective To observe the relationship between hepatitis B markers (HBV M)and HBV DNA with Pre S1. Methods Serum samples of 347 cases with HBsAg(+)as patient group and 77 cases with HBsAg(-)and HBeAg(-) as control were detected for HBV M or HBV DNA with Pre S1.Results Pre S1 positive rate in the HBeAg(+) group was higher than that in the other HBV M group(P<0 01) The sensitivity and efficiency of Pre S1 test were higher than that of HBeAg test. Pre S1 had good correlative with HBV DNA. Conclusion Pre S1 test is better than HBeAg and could be treated as a good sign in the diagnosis of hepatitis B. |
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| Keywords: | Pre S1 HBV M HBV DNA |
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