| 环磷酰胺及塞替派诱导人支气管上皮细胞恶性转化的超微结构 |
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| 引用本文： | 袁素波,王治乔,叶常青,袁本利,廖明阳.环磷酰胺及塞替派诱导人支气管上皮细胞恶性转化的超微结构[J].中国药理学与毒理学杂志,2000(5). |
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| 作者姓名： | 袁素波 王治乔 叶常青 袁本利 廖明阳 |
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| 作者单位： | 军事医学科学院毒物药物研究所!北京100850(袁素波，王治乔，袁本利，廖明阳)，军事医学科学院放射医学研究所!北京100850(叶常青) |
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| 摘 要： | 为了解抗癌化疗药环磷酰胺 (CP)及塞替派(TE)诱导的永生化人支气管上皮细胞恶性转化过程中的细胞超微结构的动态变化 ,采用透射电镜方法观察的细胞模型由对照永生化人支气管上皮细胞(BEAS- 2 B) ,受环磷酰胺 (BEAS- CP)和塞替派(BEAS- TE)诱导的恶性转化细胞组成 .发现经 CP和 TE暴露的细胞可出现细胞死亡 ,凋亡和转化 ,它们具有各自的超微结构特征 .说明逃逸细胞死亡 ,凋亡的支气管上皮基细胞呈增生性改变 ,这种增生性基细胞经过扩增后将成为转化细胞群主体并且具有肿瘤细胞的增生特性
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| 关 键 词： | 上皮细胞 支气管 人 环磷酰胺 塞替派 超微结构 |
Ultrastructure of transformed human bronchial epithelial cells induced by cyclophosphamide and thiotepa |
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| YUAN Su- Bo,WANG Zhi- Qiao,YE Chang- Qing,YUAN Ben- Li,LIAO Ming- Yang.Ultrastructure of transformed human bronchial epithelial cells induced by cyclophosphamide and thiotepa[J].Chinese Journal of Pharmacology and Toxicology,2000(5). |
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| Authors: | YUAN Su- Bo WANG Zhi- Qiao YE Chang- Qing YUAN Ben- Li LIAO Ming- Yang |
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| Institution: | YUAN Su- Bo1,WANG Zhi- Qiao1,YE Chang- Qing2,YUAN Ben- Li1,LIAO Ming- Yang1 |
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| Abstract: | In order to study features of neo- plastic transformed human bronchial epithe- lial cells transformed by cyclophosphamide (CP) and thiotepa(TE) ,the ultrastructure of the cell model system composed of the immortalized human bronchial epithelial cell line (BEAS- 2 B) ,BEAS- 2 B cell trans- formed by cyclophosphamide (BEAS- CP) and thiotepa(BEAS- TE) were investigated. After exposed to CP and TE,most BEAS- 2 B cells showed the features of cytotoxic cell death and apoptosis. The main ultra- structural features of both transformed cells were neoplastic proliferation. The trans- formed cells were stemmed from the prolif- erated basal cells which had escaped from the cell death and apoptosis. The proliferat- ed basal cells are the stem cells of malignant transformation. |
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| Keywords: | epithelium bronchial human cyclophosphamide thiotepa ultrastructure |
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