血清IGF-1、IGFBP-3水平和大肠癌关系的Meta分析

目的综合评价血清胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)水平和大肠癌的关系。方法利用Meta分析法对6篇关于血清IGF-1、IGFBP-3水平与大肠癌关系的研究文献进行定量综合分析。结果对于IGF-1，合并OR=1．56(95％CI：1．14～2．13)；按实验方法不同分层，间接酶联免疫吸附试验(ELISA)合并OR=1．92(95％CI：1．26～2．93)，IRMA法合并OR=1．23(95％CI：0．78～1．94)；对于IGFBP-3，合并OR=0．78(95％CJ：0．43～1．44)；按实验方法不同分层，ELISA法合并OR=0．46(95％CI：0．29～0．74)，免疫放射测定法(IRMA)合并OR=1．44(95％CI：0．93～2．23)。结论血清IGF-1高水平为大肠癌的独立危险因子，IGFBP-3与大肠癌的关联不具有统计学意义；IGFBP-3与大肠癌关系的各研究之间异质性是由实验方法不同而引起，但该结论尚需大样本并同时进行两种方法的测量证实。

Study on the relations between serum insulin-like growth factor-1, insulin-like growth factor binding protein-3 and colorectal cancer: a meta-analysis

Objective To evaluate the relationship between circulating levels of insulin-like growth factor-1(IGF-1),IGF-binding protein-3(IGFBP-3) and colorectal cancer. Methods A meta-analysis of 6 epidemiological studies on insulin-like growth factors and risk of colorectal cancer were performed. Results The pooled odds ratio( OR ) of IGF-1 and IGFBP-3 were 1.56 (95% CI : 1.14- 2.13 ) and 0.78 (95% CI : 0.43- 1.44 ) respectively. According to the results from different measurements(enzyme-linked immunoabsorbent assay and immunoradiometric assay),the pooled OR were 1.92 and 1.23 for IGF-1 , 0.46 and 1.44 for IGFBP-3 respectively. Conclusion High serum levels of IGF-1 were independent risk factors of colorectal cancer but the OR of IGFBP-3 was not statistically significant. The heterogeneity between studies on IGFBP-3 and colorectal cancer was caused by different measurements used,but there was still a need to conduct simultaneous large size study under 2 different measurements for further conclusion.