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t(11;18)(q21;q21) translocation as predictive marker for non-responsiveness to salvage thalidomide therapy in patients with marginal zone B-cell lymphoma with gastric involvement
Authors:Sung-Hsin Kuo  Ann-Lii Cheng  Chih-Hung Hsu  Ming-Shiang Wu  Kun-Huei Yeh  Yi-Shin Tzeng  Li-Tzong Chen
Affiliation:(1) Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan;(2) Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan;(3) Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan;(4) Cancer Research Center, National Taiwan University College of Medicine, Taipei, Taiwan;(5) National Institute of Cancer Research, National Health Research Institutes, 2F. No. 36, Sheng-Li Rd, Tainan, 70456, Taiwan;(6) Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;(7) Department of Internal Medicine, National Cheng-Kung University Hospital, Tainan, Taiwan;
Abstract:

Purpose  

Activation of TNF-α/NF-κB-related signaling pathway is crucial in sustain the growth of Helicobacter pylori-independent gastric mucosa-associated lymphoid tissue type (MALT) lymphoma. Thalidomide is an anti-angiogenic agent with anti-TNF-α and anti-NF-κB activity. This retrospective study evaluated the efficacy of thalidomide in standard therapy-failure gastric MALT lymphoma.
Keywords:
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