新生儿心力衰竭时血浆内皮素、降钙素基因相关肽和心钠素的变化及其临床意义

目的：了解血浆内皮素（ＥＴ－１）、降钙素基因相关肽（ＣＧＲＰ）和心钠素（ＡＮＦ）在新生儿心力衰竭的作用和地位。方法放射性同位素免疫分析法直接测定２８例心力衰竭新生儿不同病程时血浆中ＥＴ－１、ＣＧＲＰ和ＡＮＦ含量，并与２０例正常新生儿对比。结果心衰发生时ＥＴ－１、ＣＧＲＰ、ＥＴ－１ＣＧＲＰ、ＥＴ－１／ＡＮＦ均明显高于对照组（Ｐ〈０．０１、Ｐ〈０．０５、Ｐ〈０．０１、Ｐ〈０．０１），ＡＮＦ水平两组间无

Endothelin-1,calcitonin gene-related peptide and atrial natriuretic factor in neonatal heart failure

Objective To determine the effects of endothelin-1(ET-1),calcitonin gene-related peptide (CGRP) and atrial natriuretic factor (ANF) in physiopathology of neonatal heart failure.Methods ET-1, CGRP and ANF in the serums of 28 neonates with heart failure (HF) were continuously measured by radioimmunology and compared with 20 normal neonates.Results HF neonates had higher levels of ET-1,CGRP,ET-1/CGRP and ET-1/ANF than those of normal infants.When heart failure were controlled,serum levels of ET-1 decreased quicklly with increase of levels of CGRP and ANF.Conclusion Our work indicated that all of ET-1, CGRP and ANF play important roles in the pathologic development of neonatal heart failure.Otherwise,we thought that the effects of ET-1 might be primary and the changes of CGRP and ANF were related to ET-1.All of ET-1,CGRP and ANF are useful indicators in outcome of neonatal heart failure.