| 急性心肌梗死和脑梗死患者血浆中ADAMTS13的测定及意义 |
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| 引用本文： | 董宁征,刘芳,季顺东,阮长耿.急性心肌梗死和脑梗死患者血浆中ADAMTS13的测定及意义[J].中华血液学杂志,2008,29(3):161-163. |
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| 作者姓名： | 董宁征 刘芳 季顺东 阮长耿 |
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| 作者单位： | 苏州大学附属第一医院、汀苏省血液研究所,215006 |
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| 基金项目： | 国家自然科学基金，教育部高等学校博士学科点专项科研基金 |
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| 摘 要： | 目的 研究急性心肌梗死(AMI)及急性脑梗死(AIS)患者血浆中血管性血友病因子(vWF)裂解酶(ADAMTS13)抗原和活性变化情况,探讨ADAMTS13在动脉血栓性疾病患者发病中的作用及意义.方法 用Frests-WF73试剂盒检测血浆中ADAMTS13的活性;用ELISA法检测ADAMTS13抗原含量;并对患者血浆vWF多聚物进行电泳分析.结果 正常对照组、AMI组和AIS组ADAMTS13抗原含量分别为(878±198)、(618±188)和(702±155)U/L;活性分别为(81.7±13.9)%,(59.2±22.1)%和(65.4±15.8)%.AMI组和AIS组ADAMTS13抗原含量及活性均显著低于正常对照组(P《0.01);vWF多聚物分析未见异常.结论 AMI及AIS患者血浆ADMATS13抗原及活性均降低,提示ADAMTS13的减少与动脉血栓性疾病的发病相关.
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| 关 键 词： | 血管性血友病因子裂解酶 心肌梗死 脑梗死 |
Determination of ADAMTS13 antigen and activity levels in patients with acute myocardial infarction and acute ischemic stroke |
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| DONG Ning-zheng,LIU Fang,JI Shun-dong,RUAN Chang-geng.Determination of ADAMTS13 antigen and activity levels in patients with acute myocardial infarction and acute ischemic stroke[J].Chinese Journal of Hematology,2008,29(3):161-163. |
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| Authors: | DONG Ning-zheng LIU Fang JI Shun-dong RUAN Chang-geng |
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| Institution: | iangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China. |
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| Abstract: | OBJECTIVE: To investigate the ADAMTS13 antigen levels and activity in patients with acute myocardial infarction (AMI) and acute ischemic stroke (AIS), and explore its significance in these diseases. METHODS: ADAMTS13 activity levels were detected by a new developed Frests-vWF73 kit, ADAMTS13 antigen levels by ELISA kit, and vWF multimers by electrophoresis. RESULTS: ADAMTS13 antigen in normal control, AMI and AIS was (878 +/- 198), (618 +/- 188) and (702 +/- 155) U/L, and ADAMTS13 activity was (81.7 +/- 13.9)%, (59.2 +/- 22.1 )% and (65.4 +/- 15.8)%, respectively, being significantly decreased in AMI and AIS patients. CONCLUSION: ADMATS13 might involve in arterial infarction diseases. |
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