The use of household cleaning products during pregnancy and lower respiratory tract infections and wheezing during early life |
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Authors: | Lidia Casas Jan Paul Zock Anne Elie Carsin Ana Fernandez-Somoano Ana Esplugues Loreto Santa-Marina Adonina Tardón Ferran Ballester Mikel Basterrechea Jordi Sunyer |
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Affiliation: | 1. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain 2. Hospital del Mar Research Institute (IMIM), Barcelona, Spain 3. CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain 4. University of Oviedo, Oviedo, Spain 5. Center for Public Health Research-CSISP, Valencia, Spain 6. Subdirección de Salud Pública de Gipuzkoa, Departamento de Sanidad, Gobierno Vasco, San Sebastián, Spain 7. Instituto de Investigación Sanitaria Biodonostia, San Sebastián, Spain 8. University of Valencia, Valencia, Spain 9. Pompeu Fabra University, Barcelona, Spain
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Abstract: | Objective To evaluate the effects of household use of cleaning products during pregnancy on infant wheezing and lower respiratory tract infections (LRTI). Methods In four prospective Spanish birth cohorts (n = 2,292), pregnant women reported the use of household cleaning products. When infants were 12–18 months old, current cleaning product use and infant’s wheezing and LRTI were reported. Cohort-specific associations between the use of specific products and respiratory outcomes were evaluated using multivariable regression analyses and estimates were combined using random-effects meta-analyses. Results The period prevalence of LRTI was higher when sprays (combined odds ratio (OR) = 1.29; 95 % confidence interval (CI) 1.04–1.59) or air fresheners (OR = 1.29; CI 1.03–1.63) were used during pregnancy. The odds of wheezing increased with spray (OR = 1.37; CI 1.10–1.69) and solvent (OR = 1.30; CI 1.03–1.62) use. The associations between spray and air freshener use during pregnancy and both outcomes remained apparent when these products were not used after pregnancy. Nevertheless, the estimates were higher when post-natal exposure was included. Conclusion The use of cleaning sprays, air fresheners and solvents during pregnancy may increase the risk of wheezing and infections in the offspring. |
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